Tietz Textbook of Clinical Chemistry and Molecular Diagnostics book cover

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics

As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics.

Online version,

Published: January 2012

Imprint: Saunders

ISBN: 978-0-323-08985-2


  • Section I: Principles of Laboratory Medicine

    1. Introduction to Laboratory Medicine
    2. Selection and Analytical Evaluation of Methods - With Statistical Techniques
    3. Clinical Evaluation of Methods
    4. Evidence Based Laboratory Medicine
    5. Establishment and Use of Reference Values
    6. Preanalytical Variables and Biological Variation
    7. Specimen Collection and Processing
    8. Quality Management
    9. Section II: Analytical Techniques and Instrumentation

    10. Principles of Basic Techniques and Laboratory Safety
    11. Optical Techniques
    12. Electrochemistry and Chemical Sensors
    13. Electrophoresis
    14. Chromatography and Extraction
    15. Mass Spectrometry
    16. Enzyme and Rate Analyses
    17. Principles of Immunochemical Techniques
    18. Nucleic Acid Techniques
    19. Microfabrication and Microfluidics and Their Application to Clinical Diagnostics
    20. Automation in the Clinical Laboratory
    21. Point-of-Care Testing
    22. Section III: Analytes

    23. Amino Acids, Peptides, and Proteins
    24. Serum Enzymes
    25. Enzymes of the Red Blood Cell
    26. Tumor Markers
    27. Kidney Function Tests
    28. Carbohydrates
    29. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors
    30. Electrolytes and Blood Gases
    31. Hormones
    32. Catecholamines and Serotonin
    33. Vitamins and Trace Elements
    34. Hemoglobin, Iron, and Bilirubin
    35. The Porphyrias and Other Disorders of Porphyrin Metabolism
    36. Therapeutic Drugs and Their Management
    37. Clinical Toxicology
    38. Toxic Metals
    39. Section IV: Molecular Diagnostics and Genetics

    40. Principles of Molecular Biology
    41. Genomes and Nucleic Acid Alterations
    42. Nucleic Acid Isolation
    43. Inherited Diseases
    44. Identity Assessment
    45. Molecular Methods in Diagnosis and Monitoring of Infectious Diseases
    46. Pharmacogenetics
    47. Hematopoietic Malignancies
    48. Plasma Nucleic Acids
    49. Section V: Pathophysiology

    50. Diabetes Mellitus
    51. Cardiovascular Disease
    52. Kidney Disease
    53. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
    54. Liver Disease
    55. Gastrointestinal and Pancreatic Diseases
    56. Disorders of Bone and Mineral Metabolism
    57. Pituitary Function and Pathophysiology
    58. The Adrenal Cortex
    59. The Thyroid: Pathophysiology and Thyroid Function Testing
    60. Reproductive Endocrinology and Related Disorders
    61. Pregnancy and its Disorders
    62. Newborn Screening and Inborn Errors of Metabolism
    63. Hemostasis
    64. Section VI: Appendix

    65. Reference Information for the Clinical Laboratory


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