Tietz Fundamentals of Clinical Chemistry book cover

Tietz Fundamentals of Clinical Chemistry

A condensed, student-friendly version of Tietz Textbook of Clinical Chemistry, this text uses a laboratory perspective to provide you with the chemistry fundamentals you need to work in a real-world, clinical lab. Accurate chemical structures are included to explain the key chemical features of relevant molecules. Offering complete, accurate coverage of key topics in the field, it's everything that you expect from the Tietz name!

Book, 976 Pages

Published: November 2007

Imprint: Saunders

ISBN: 978-1-4557-3440-5


  • NEW REVIEW -- BURTIS / Tietz Fundamentals of Clinical Chemistry, 6th Edition.
    Elsevier, 2008, $96.95. Imprint: Saunders.

    Burtis, Carl A., PhD; Ashwood, Edward R., MD; Bruns, David E., MD

    ISBN: 978-0-7216-3865-2, NLM: QY 90, LC: RB40, 952 pages, hard cover.


    Valerie L. Ng, PhD, MD(Alameda County Medical Center/Highland Hospital)

    This is the sixth edition of what is appropriately recognized as one of the cornerstone reference books for clinical chemistry. The fifth edition was published 2001.

    This is as a comprehensive clinical chemistry book.

    Intended for anyone interested in clinical chemistry, the book would be of obvious use to clinical laboratory scientists (practicing or in training) or clinical chemists (fellows or practicing). It would also be of interest to clinical pathologists (residents or practicing). Finally, it would be of interest to anyone who orders any of these tests and uses them to help in clinical care (i.e., MDs, medical students, residents, fellows, nurse practitioners, etc.) The editors and authors are well known and credible authorities.

    Every time I turn around, there's a new Tietz clone. Specifically, all released within the past year or so and all edited by the same group, there is this sixth edition, there is the fourth edition of the Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Burtis et al. (Elsevier,
    2006) (mammoth combo book), and there is the newly released Fundamentals of Molecular Diagnostics, Bruns et al (Elsevier, 2007). How do these three books interrelate? This sixth edition nicely carries on the tradition of excellence long associated with Tietz Fundamentals of Clinical Chemistry. Of note and unique to this book (compared to the two other Tietz variants) is a standardized chapter format beginning with key words and key concepts and ending with self-assessment questions. Additional material is available on the Evolve website for the more curious. But how come this 952-page book is only about one-third the size of the Tietz Textbook, even though it has only 11 fewer chapters? And why does it have 1,460 fewer pages than the Tietz Textbook, when the molecular diagnostics book has only 267 pages? So here's the difference: this book is focused primarily on the laboratory aspects of clinical chemistry.
    While organ systems and clinical relevance of tests are discussed in this book, they are not discussed in the detail or depth as in the textbook. This book is nicely designed for the student with integrated educational tools. The textbook has much more detailed information but lacks integration with educational aids.
    The molecular diagnostics book has more current information than the textbook.
    Finally, in terms of weight, the molecular diagnostics book is lightweight, the fundamentals book is near the limit of my lifting capacity, and the textbook - you can injure yourself trying to heft it around if your upper body strength is limited like mine. If you want the best bang for your buck though, I'd recommend the textbook, but make sure you buff up at the gym before regular use.

    This fundamentals book is a nice update to a well recognized authoritative text on clinical chemistry. I'd heartily recommend this for CLS students and clinical chemistry fellows. Meanwhile, I'd recommend the textbook for practicing pathologists/clinical chemists/pathology residents for the extra detail and depth needed for everyday practice.


    Weighted Numerical Score: 94 - 4 Stars!



    1. Introduction to Clinical Chemistry and Evidence-Based Laboratory Medicine

    2. Introduction to Principles of Laboratory Analyses and Safety

    3. Specimen Collection and Other Pre-Analytical Variables


    4. Optical Techniques

    5. Electrochemistry and Chemical Sensors

    6. Electrophoresis

    7. Chromatography

    8. Mass Spectrometry

    9. Principles of Clinical Enzymology

    10. Principles of Immunochemical Techniques

    11. Automation in the Clinical Laboratory

    12. Point-of-Care Testing


    13. Selection and Analytical Evaluation of Methods — With Statistical Techniques

    14. Establishment and Use of Reference Values

    15. Clinical Laboratory Informatics

    16. Quality Management


    17. Nucleic Acids

    18. Amino Acids and Proteins

    19. Enzymes

    20. Tumor Markers

    21. Creatinine, Uric acid, and Urea

    22. Carbohydrates

    23. Lipids, Lipoproteins, and Cardiac Risk Factors

    24. Electrolytes and Blood Gases

    25. Hormones

    26. Catecholamines and Serotonin

    27. Vitamins and Trace Elements

    28. Hemoglobin, Iron, and Bilirubin
    29. Porphyrins and Disorders of Porphyrin Metabolism

    30. Therapeutic Drugs

    31. Clinical Toxicology

    32. Toxic Metals


    33. Cardiovascular Disease

    34. Renal Disease

    35. Disorders of Water, Electrolyte, and Acid-Base Metabolism

    36. Liver Disease

    37. Gastric, Pancreatic, and Intestinal Diseases

    38. Disorders of Bone

    39. Pituitary Disorders

    40. Adrenal Cortical Disorders

    41. Thyroid Disorders

    42. Reproductive Disorders

    43. Disorders of Pregnancy

    44. Newborn Screening


    45. Reference Information for the Clinical Laboratory

    Appendix: Review Questions



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