Therapeutic Applications of Quadruplex Nucleic Acids
By- Stephen Neidle, The School of Pharmacy, University of London, UK
Hardbound, 208 Pages
Published: September 2011
Imprint: Academic Press
ISBN: 978-0-12-375138-6
Contents
- Intro - history and milestones
- Fundamentals of DNA and RNA quadruplex structure and stability
- Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance
- Genomic DNA and RNA quadruplexes - involvement in gene expression and potential as therapeutic agents
- Quadruplex targets and human disease - applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit
- Quadruplex ligands - chemistry and design - selectivity and assays
- Quadruplex ligands - basic biology and assays indirect and direct
- Quadruplex ligands - pharmacology and druggability, ligands in clinical trial and pre-clinical trial development
- Synthetic quadruplexes and drugs - therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding
- Future directions and conclusions
