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The Proteasomal System in Aging and Disease

This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease.

Audience
Molecular biologists and researchers of proteasomes

Hardbound, 436 Pages

Published: July 2012

Imprint: Academic Press

ISBN: 978-0-12-397863-9

Contents

    1. Structure of the Proteasome

      2. Tobias Jung and Tilman Grune

    2. Structure and Function of the Ubiquitin-Proteasome System: Modulation of Components

      3. Niki Chondrogianni and Efstathios S. Gonos

    3. Immunoproteasomes: Structure, Function, and Antigen Presentation

      4. Deborah A. Ferrington and Dale S. Gregerson

    4. Interactions of the Proteasomal System with Chaperones - Protein Triage and Protein Quality Control

      5. Marc Kästle and Tilman Grune

    5. Proteasome Inhibitors

      6. Boris Cvek

    6. Degradation of Damaged Proteins - The Main Function of the 20S Proteasome

      7. Andrew. M. Pickering and Kelvin. J. A. Davies

    7. Changes of the Proteasomal System During the Aging Process

      8. Martin A. Baraibar and Bertrand Friguet

    8. Proteasome and Cancer

      9. Betul Catalgol

    9. The Ubiquitin Proteasome System and Cardiovascular Disease.

      10. Saul R. Powell, Joerg Herrmann, Amir Lerman, Cam Patterson, Xuejun Wang

    10. Role of the Ubiquitin-Proteasome in Protein Quality Control and Signaling: Implication in the Pathogenesis of Eye Diseases

      11. Fu Shang and Allen Taylor

    11. Proteasome and Neurodegenerative Diseases

    Betul Catalgol and Tilman Grune

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