E. Scharrer - W. Bargmann Memorial Lecture. 1. Brain secretory peptides of the silkmoth Bombyx mori: Prothoracicotropic hormone and bombyxin (H. Ishizaki and A. Suziki). Evolutionary aspects of neuropeptides and their genes. 2. Structure and evolution of insulin and insulin-like growth factors in chordates (S.J. Chan, S. Nagamatsu, Q.-P. Cao and D.F. Steiner). 3. Relationships among the FMRFamide-like peptides (M.J. Greenberg and D.A. Price). 4. Molecular evolution of neurohypophysial hormone precursors (A. Urano, S. Hyodo and M. Suzuki). 5. A vasopressin-related peptide in the mollusc Lymnaea stagnalis: peptide structure, prohormone organization, evolutionary and functional aspects of Lymnaea conopressin (R.E. van Kesteren, A.B. Smit, N.D. de With, J. van Minnen, R.W. Dirks, R.C. van der Schors and J. Joosse). Molecular biology of neuropeptides - Regulation of neuropeptide genes. 6. Models for the study of cell-specific neuropeptide gene expression (S. Wray and H. Gainer). 7. Neuropeptide gene expression in transgenic animals (D. Murphy, H.-L. Ang, Q. Zeng, M.-Y. Ho, J. Funkhauser and D. Carter). 8. Spatiotemporal patterns of transcription factor gene expression accompanying the development and plasticity of cell phenotypes in the neuroendocrine system (L.W. Swanson). 9. Alternative mRNA splicing in the nervous system (J.F. Burke, K.E. Bright, E. Kellet, P.R. Benjamin and S.E. Saunders). 10. Regulation of vasopressin and oxytocin gene expression by estrogen and thyroid hormones (R.A.H. Adan and J.P.H. Burbach). 11. The peptidergic nervous system of coelenterates (C.J.P. Grimmelikhuijzen, D. Darmer, C. Schmutzler, K. Carstensen, H.-P. Nothacker, R.K. Reinscheid, K.L. Rinehart and I.D. McFarlane). 12. Mutant vasopressin precursor producing cells of the homozygous Brattleboro rat as a model for co-expression of neuropeptides (F.W. van Leeuwen). 13. Purification of a new neuropeptide from locust corpus cardiacum which influences ileal transport (N. Audsley, C. McIntosh and J.E. Phillips). Differentiation and development of peptidergic neurons. 14. Molecular genetic analysis of the FMRF-amide-related neuropeptides in Drosophila (P.H. Taghert, M.A. O'Brien, L.E. Schneider and M.S. Roberts). 15. Somatostatin: a putative neurotrophic factor with pleiotropic activity in the rat central nervous system (P. Leroux, B.J. Gonzalez, C. Bodenant, C. Bucharles and H. Vaudry). 16. Topographical displacement of neuropeptide-producing nuclei as an indicator of evolutionary brain development (S. Blähser). Receptors and peptide analogues. 17. Molecular biology of G-protein-coupled receptors (G.J.M. Martens). 18. Strategies in the development of peptide antagonists (V.J. Hruby). 19. Antibodies to neuropeptides as alternatives for peptide receptor antagonists in studies on the physiological actions of neuropeptides (J.W.A.M. van Oers, C. van Bree, A. White and F.J.H. Tilders). Processing, transport and release. 20. The biosynthesis and processing of neuroendocrine peptides: identification of proprotein convertases involved in intravesicular processing (S.P. Smeekens, S.J. Chan, D.F. Steiner). 21. Synexin (Annexin VII) and membrane fusion during the process of exocytotic secretion (H.B. Pollard, E. Rojas and A.L. Burns). 22. Routing and release of input and output messengers of peptidergic systems (E.W. Roubos). Membrane physiology and second messenger systems. 23. Signal transduction in the neurohypophyseal compartments (W.T. Mason, G.I. Hatton, M. Kato and R.J. Bicknell). 24. Synaptic and neurotransmitter regulation of activity in mammalian hypothalamic magnocellular neurosecretory cells (L.P. Renaud, A. Allen, J.T. Cunningham, C. Jarvis, S. Johnston, R. Nissen, M. Sullivan, E. Van Vulpen and C.R. Yang). Periodicity of peptidergic systems. 25. Neurotransmitter colocalization and circadian rhythms (H.E. Albers, S.-Y. Liou, E.G. Stopa and R.T. Zoeller). 26. Cellular oscillators and biological timing: the role of proteins and Ca2+ (F. Strumwasser and J.M. Vogel). 27. Peptidergic transmitters of the suprachiasmatic nuclei and the control of circadian rhythmicity (A. Kalsbeek and R.M. Buijs). Organismic biology of invertebrate and vertebrate peptidergic systems. 28. Cholecystokinin in the control of ingestive behavior (P. Södersten, G. Forsberg, I. Bednar, A. Lindén and G.A. Qureshi). 29. Egg laying in the hermaphrodite pond snail Lymnaea stagnalis (A. ter Maat). 30. The eclosion hormone system of insects (J.W. Truman). 31. Opioid peptides, pain and stress (L. Terenius). 32. The anti-gonadotropic neuropeptide schistosomin interferes with peripheral and central neuroendocrine mechanisms involved in the regulation of reproduction and growth in the schistosome-infected snail Lymnaea stagnalis (M. de Jong-Brink, P.L. Hordijk, D.P.E.J. Vergeest, H.D.F.H. Schallig, K.S. Kits and A. ter Maat). Subject index.