The Parathyroids

Basic and Clinical Concepts

Edited by

  • John P. Bilezikian, MD, Professor of Medicine and Pharmacology; Chief, Division of Endocrinology; Director, Metabolic Bone Diseases Program, Departments of Medicine and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
  • Robert Marcus, MD, Emeritus, Department of Medicine, Stanford University School of Medicine, CA, USA
  • Michael Levine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA

Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians.
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Students, researchers, fellows, and professionals in endocrinology and bone/mineral research.


Book information

  • Published: June 2001
  • ISBN: 978-0-12-098651-4


"...a comprehensive source of information that most endocrinologists will want to have on their bookshelves." -TRENDS IN ENDOCRINOLOGY AND METABOLISM (April 2003) "It represents a significant contribution to the field, and likely will continue to do so for many editions." —Bart L. Clarke, Mayo Clinic, for DOODY PUBLISHING REVIEWS (2002)

Table of Contents

Basic Elements of the Parathyroid System Embryology, Anatomy, and Pathology Parathyroid Hormone: Gene Structure, Biosynthesis, Metabolism Parathyroid Hormone-related Protein: Gene Structure, Biosynthesis, MetabolismStructure-function Analysis of PTH and PTHRP Receptors for Parathyroid Hormone and PTHRP: Signaling and Regulation Nuclear targeting: Signaling for PTHRP Signal Transduction of PTH and PTHRP Receptors and Signaling for Calcium Ion Immunoassays for PTH and PTHRP: Clinical Applications Physiological Aspects of the Parathyroids Physiology of Calcium Homeostasis Anabolic and Catabolic Effects of Parathyroid Hormone on Bone: Interaction with Growth Factors Cellular Actions of Parathyroid Hormone on Osteoblast and Osteoclast Differentiation Physiological Actions of PTH and PTHRP I: Skeletal ActionsPhysiological Actions of PTH and PTHRP II: Renal ActionsPhysiological Actions of PTH and PTHRP III: Chondrocyte, Tooth, and Bone Development Physiological Actions of PTH and PTHRP IV: Vascular and Cardiovascular, Neurological ActionsPhysiological Actions of PTH and PTHRP V: Mammary, Reproductive, Epidermal, and Pancreatic Tissue - PTH and PTHRP as Polyhormones Clinical Aspects Primary Hyperparathyroidism Normal and Abnormal Growth of Parathyroid Cells Molecular Genetics of Primary Hyperparathyroidism Clinical Presentation of Primary Hyperparathyroidism: US Clinical Presentation of Primary Hyperparathyroidism: Europe Clinical Presentation of Primary Hyperparathyroidism: India, Brazil, China Clinical Course of Primary Hyperparathyroidism Bone Turnover in Primary Hyperparathyroidism Cytokines in Primary Hyperparathyroidism Histomorphometric Analysis of Bone in Primary Hyperparathyroidism Nephrolithiasis in Primary Hyperparathyroidism Guidelines for the Medical or Surgical Management of Primary Hyperparathyroidism Medical Management of Primary Hyperparathyroidism Preoperative Localization of Parathyroid Tissue in Primary Hyperparathyroidism Surgical Management of Primary Hyperparathyroidism Ectopic Locations of Parathyroid Glands Parathyroid Carcinoma Acute Primary Hyperparathyroidism Multiple Endocrine Neoplasia Type I Multiple Endocrine Neoplasia Type II Familial Forms of Primary Hyperparathyroidism Familial Hypocalciuric Hypercalce Secondary Hyperparathyroidism Parathyroids in Renal Disease: Pathophysiology Hyperparathyroidism in Renal Failure: Clinical Features, Diagnosis, and Management Special Considerations Evaluation of the Hypercalcemic Patient: Differential Diagnosis Hypercalce Due to PTHRP Other Local and Ectopic Secretion Syndromes Associated with Hypercalce Jansen's Disease Acute Management of Hypercalce Primary Hyperparathyroidism and Other Causes of Hypercalce in Children and Adolescents The Hypoparathyroid States Hypoparathyroidism in Differential Diagnosis of Hypocalce Parathyroid Function in Magnesium Deficiency Molecular Genetics of Hypoparathyroidism Autoimmune Aspects of Hypoparathyroidism Pseudohypoparathyroidism: Clinical, Biochemical, and Molecular features Treatment of Hypoparathyroidism The Parathyroids in Osteoporosis Parathyroid Function in the Normal Aging Process Parathyroid Function and Responsiveness in Osteoporosis Parathyroid Hormone and Growth Hormone in the Treatment of Osteoporosis