The Organic Chemistry of Drug Design and Drug Action
- Richard Silverman, Ph.D Organic Chemistry, Northwestern University Department of Chemistry Department of Biochemistry, Molecular Biology, and Cell Biology Drug Discovery Program
Students in medicinal chemistry, the principles of drug design, advanced organic and bioorganic chemistry, researchers in pharmacology and organic chemistry, and drug companies.
- Published: March 1992
- Imprint: ACADEMIC PRESS
- ISBN: 978-0-12-643730-0
"This book is a tour de force in the title area....This book adopts a novel format that focuses on the rational chemical underpinnings to both drug discovery and drug development. It seeks to illuminate the workings of drugs at the molecular level. Thus, this book contrasts with the traditional presentation which is organized around various classes of drugs....This book would be appropriate for advanced undergraduate students and graduate students and would probably be well suited as a text for course applications, especially at the graduate level. It is strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration." --Bruce E. Maryanoff, R.W. Jouhnson Pharnaceutical Research Institute, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vo. 115, No.12, 1993 "For the first time the principles of medicinal chemistry/pharmacology are collected in a unified, well-organized and clearly presented fashion. It is so clearly written that it will be of value to both students and veteran scientists...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data so as to truly begin to reduce medicinal chemistry from a hybrid of chemistry, pharmacology and related sciences to a single, clearly defined, rationalized discipline." --CARL KAISER, Ph.D., Director, Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION "The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way...The book will turn out to be very popular with students because the material is presented clearly...The numerous superb illustrations included are used very effectively by the author to communicate and/or clarify concepts and ideas." --William C. Groutas, Ph.D., Professor of Chemistry, WICHITA STATE UNIVERSITY "I find [Chapter 8] to be an unusually comprehensive, clear and well organized discussion on prodrugs.