The Neuroendocrine Immune Network in Ageing

Edited by

  • R.H. Straub, University Medical Center, Department of Internal Medicine I, Laboratory of Neuroendocrinoimmunology, Regensburg, Germany
  • Eugenio Mocchegiani, MD, Professor and Director, Section of Nutrition, Immunity, and Ageing, Immunology Centre, INCRA (Italian National Research Centres on Aging), and University of Ancona, Department of Food Sciences, Nutrition and Aging Centre, Ancona, Italy

The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity.
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Book information

  • Published: July 2004
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-51617-6


" a welcome addition to biogerontological literature...the wealth of information provided with respect to the ageing brain, the immune system and the hormonal system is definately highly useful to venture into other areas of biogerentology." - BIOGERONTOLOGY (2005) "...offers a good overview of some of the studies carried out to help address these questions, focusing particularly on the neuro-endocrine-immune axis...Overall, this text offers a good overview of the aging of the immune, neural and endocrine systems, and enables the appreciation of how biological aging of one system influences the other." -Meharvan Singh, PhD, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, U.S.A. (2005)

Table of Contents

I. Introduction.
Evolutionary aspects for the neuroendocrine immune network and ageing (R.H. Straub).

II. Ageing of the immune system.
Immunosenescence (R. Solana, G. Pawelec). Zinc-binding proteins (metallothionein and α-2 macroglobulin) as potential biological markers of immunosenescence (E. Mocchegiani et al.). Neutrophil ageing and immunosenescence (S.K. Butcher et al.). Apoptosis and ageing (A. Larbi et al.). MHC-unrestricted cytotoxicity in ageing (M. Provinciali, A. Donnini, R.E. Francesca). Major histocompatibility complex polymorphisms and ageing (G. Candore et al.).

III. Ageing of the endocrine system.
Neuroplascticity in the human hypothalamus during ageing (M.A. Hofman, D.F. Swaab). The role of growth hormone signalling in the control of ageing (A. Bartke et al.). Ageing and the adrenal cortex (V. Lamounier-Zepter, S.R. Bornstein). Hormonal changes in ageing men (E. Plas, S. Madersbacher, P. Berger). Ageing and the endocrine circadian system (Y. Touitou, E. Haus). Melatonin rhythms, melatonin supplementation and sleep in old age (R.F. Riemersma et al.).

IV. Ageing of the nervous system.
Age-related changes of the human autonomic nervous system (M. Agelink, R. Malessa, D. Ziegler). Age-related alterations in autonomic nervous innervation (D.L. Bellinger, K.S. Madden, D. Lorton). Ageing and the neuroendocrine system of the gut (M. El-Salhy). Modulating effects of nutrition on brain ageing (C. Bertoni-Freddari et al.). Ageing-related role of nitric oxide in the brain (S. Mariotto et al.).

V. Links between one global system and another global system during the ageing process.
Introduction (R.H. Straub). Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: Role of zinc (E. Mocchegiani et al.). Adverse lucocorticoid actions and their relevance to brain ageing (K. Dinkel, R.M. Sapolsky). Neuroendocrine immune aspects of osteoporosis during the ageing process (M. Peterlik).

VI. The ageing process and chronic inflammatory diseases.
Neuroendocrine immune mechanisms of accelerated ageing in patients with chronic inflammatory diseases (R.H. Straub, J. Schölmerich, M. Cutolo). Thyroid autoimmunity and ageing (S. Mariotti, G. Pinna, A. Pinchera). The clinical importance of proinflammatory cytokines in elderly populations (H. Bruunsgaard, K. Krabbe).

VII. Conclusions.
Possible new anti-ageing strategies related to neuroendocrine immune interactions (E. Mocchegiani, R.H. Straub). Concluding remarks and future directions (I. Berczi, A. Szentivanyi).