The Molecular Basis of Cancer

By

  • John Mendelsohn, MD, Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
  • Peter Howley, MD, Shattuck Professor of Pathological Anatomy, Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, Massachusetts
  • Mark Israel, MD, Director, Norris Cotton Cancer Center, Professor of Pediatrics and Genetics, Dartmouth Medical School, Hanover, New Hampshire
  • Joe Gray, PhD, Gordon Moore Professor and Chair, Biomedical Engineering, Oregon Health and Science University (OHSU) Director, OHSU Center for Spatial Systems Biomedicine, Portland, Oregon; Emeritus Professor, UCSF, and Visiting Faculty, Lawrence Berkeley National Laboratory, Berkeley, California
  • Craig Thompson, MD, President and CEO, Memorial Sloan-Kettering Cancer Center, New York, New York

The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application.
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Audience

Oncology and Hematology

 

Book information

  • Published: February 2014
  • Imprint: SAUNDERS
  • ISBN: 978-1-4557-4066-6


Contents

The Molecular Basis of Cancer, 4e

Mendelsohn, Howley, Israel, Gray, Thompson

 

Part I: Carcinogenesis and Cancer Genetics

1. Cancer, A Genetic Disorder

2. Oncogenes and Signal Transduction

3. Tumor Suppressor Genes

4. Genomic Instability and DNA Repair

5. Epigenetics and Cancer

6. Infectious Agents and Cancer

7. Environmental Carcinogenesis

8. Animal Models: Flies, Fish and Yeast

9. Genetic Mouse Models of Cancer

Part II: Cancer Biology

10. Cancer Stem Cells

11. Regulation of the Cell Cycle

12. Cell Growth

13. Cancer Cell Metabolism

14. Apoptosis, Autophagy and Necrosis

15. Cell Growth Arrest and Senescence

  16. Stromal-Cancer Interactions in the Microenvironment

  17. Hypoxia and Angiogenesis

18. Invasion and Metastasis

19. Inflammation and Cancer

  20. Molecular Pathways and Systems Biology

Part III: Molecular Pathology and Diagnostics

21. Biomarkers Assessing Risk of Cancer

22. Biomarkers for Detecting Cancer: Molecular Screening

  23. Biomarkers for Predicting Response to Specific Therapy

24. The Technology of Analyzing Nucleic Acids

25. Imaging Cancer