The Laboratory MouseEdited by
- Hans Hedrich, Institute for Laboratory Animal Science, Hannover Medical School, Germany
Among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. They comprise the majority of all experimental mammals and tend to be the model of choice used for research into many diseases/disorders including cancer, heart disease, asthma, Alzheimers, Down syndrome, deafness, osteoporosis, obesity, diabetes and even mental health research. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project.One of the most time-consuming activities in research laboratories is looking up information specific to the species or strain of animal being used. This book, part of the highly successful Handbook of Experimental Animals series, allows the user quick access to any point of interest on the mouse as an experimental model.
Researchers and students in biological, veterinary and medical sciences, as well as researchers in the pharmaceutical industry.
Hardbound, 656 Pages
Published: August 2004
Imprint: Academic Press
"...a good reference on a broad range of mouse-related topics. ...the book is recommended for pathologists working in genomics research and for departmental-level libraries." - Dr. C. B. Clifford, Charles River Laboratories for JOURNAL OF VETERINARY PATHOLOGY (2005) "The many line drawings, gray-tone and color photographs, photomicrographs, charts, and tables are clear, are placed adjacent to relevant text, and have self-explanatory legends. The ullustrations add greatly to the usefulness of the book...it would be hard to find one that provides so much current and research-relevant information in one place." - Lauretta W. Gerrity, University of Alabama at Birmingham in AMERICAN JOURNAL OF ROENTGENOLOGY "...well written and offer interesting background information for anyone in this field...this book would be a useful addition to the bookshelves of those readers of Neuromuscular Disorders who use, or plan to use, mouse models in their research. The book provides an overview of the whole field, that may help in the generation of licensing and grant applications and may, through references, suggest for more specific, detailed information." - Neuromuscular Disorders (2005) "...easy to navigate and highly informative without being oppressive. The Laboratory Mouse will be a welcome addition to the student research assistant, as well as the seasoned researcher in the broad, reaching fields of human and veterinary medicine." -Animal Lab News (June 2005) "Numerous texts are available covering the laboratory mouse. Do we really need another? After reading this book, the answer is clearly yes. This text brings together information about numerous aspects of working with the laboratory mouse into one complete reference...This book should be on the shelves of geneticists, pathologists, researchers, veterinarians, and students as a valuable reference...The chapters covering mouse anatomy and pathology are an excellent companion to other pathology and anatomy texts...These chapters strengthen this text and make it the one book to reach for first. Especially valuable are the mouse as a model for a particular organ systems...this text is a welcome addition to the bookshelves of all those involved with laboratory mice. This well-researched text with numerous tables and photographs will be used for many years to come." - Contemporary Topics (2005)
- History, Development and Genetics of the Mouse as a Laboratory ModelOrigin of the Laboratory Mouse and Related Historical Foundations Strain, Stock and Mutants Mouse Genomics Generation of Mouse Mutants by Sequence Information Driven and Random Mutagenesis The Mouse as an Animal Model for Human DiseasesThe Mouse in Preclinical Safety Studies Anatomy and Developmental BiologyGross Anatomy Normative Histology of Organs Imaging Introduction to Early Mouse Development Pathophysiology (including non-infectious diseases)Skin and Adnexes of the Laboratory Mouse Cardiovascular System Respiratory Tract Gastrointestinal System and Metabolism Inbred Mouse Models for Autoimmune Disease Hematology of the Mouse The Social Behaviour of Mice and its Sensory Control Neuroendocrine Immune Network in Stress Circadian Rhythms of the Mouse Gerontology Diversity of Spontaneous Neoplasms in Commonly Used Inbred Strains and Stock of Laboratory Mice Infectious Agents and DiseasesViral Infections Animal Husbandry and ProductionHousing and MaintenanceGnotobiology and Breeding Techniques Assisted Reproduction and Cryopreservation Health Monitoring Nutrition of Laboratory Mice ProceduresLegal Regulations for the Protection of Animals Used for Scientific Experiments Necropsy Methods Handling and Restraint Routes of Administration Collection of Body Fluids Anaesthesia, Analgesia and Euthanasia