The Harriet Lane Handbook of Pediatric Antimicrobial Therapy

Mobile Medicine Series (Expert Consult: Online + Print)


  • Julia McMillan, MD, Professor of Pediatrics Associate Dean for Graduate Medical Education Johns Hopkins University School of Medicine Baltimore, Maryland
  • Carlton Lee, PharmD, MPH, Clinical Pharmacy Specialist, Pediatrics Program Director, Pediatric Pharmacy Residency Department of Pharmacy The Johns Hopkins Hospital; Associate Professor, Pediatrics Johns Hopkins University School of Medicine Baltimore, Maryland
  • George Siberry, MD, MHP, Assistant Professor Department of Pediatrics Johns Hopkins University School of Medicine Baltimore, Maryland
  • Karen Carroll, MD, Director, Division of Medical Microbiology Director, Medical Microbiology Fellowship Program Professor of Pathology Johns Hopkins University School of Medicine Baltimore, Maryland

From the experts at Johns Hopkins University who bring you the bestselling Harriet Lane Handbook, the Harriet Lane Handbook of Pediatric Antimicrobial Therapy delivers quick, dependable answers to help you effectively treat a broad spectrum of pediatric infectious diseases. This highly regarded medical reference book is your pocket-sized source for all of the evidence-based recommendations you need to provide the best possible care to your young patients.
View full description




Book information

  • Published: July 2013
  • Imprint: SAUNDERS
  • ISBN: 978-0-323-11247-5


"...straighforward language and sound structure, with a wealth of information available in pocket form for the busy house officer or resident in pediatric departments all over the world. I can only give my highest recommendation."
International Journal of Adolescent Medicine and Health, 2009

Table of Contents


Notes and Abbreviations Used in Tables

1. Infectious Agents and Drugs of Choice

I. Recommended Treatment for Bacterial Infections

II. Recommended Treatment for Mycobacterial Infections

III. Recommended Treatment for Viral Infections

IV. Recommended Treatment for Fungal Infections

V. Recommended Treatment for Parasitic and Protozoal Infections

2. Recommended Empiric Antimicrobial Therapy for Selected Clinical Syndromes

3. Drug Dosing in Special Circumstances

4. Mechanisms of Action and Routes of Administration of Antimicrobial Agents

5. Mechanisms of Drug Resistance

I. Common Mechanisms of Microbial Resistance

II. Discordance Between in Vitro Susceptibility and in Vivo Efficacy

6. Therapeutic Drug Monitoring

I. General Principles

II. Antimicrobials Requiring Therapeutic Drug Monitoring

III. Special Topics in Antimicrobial Therapeutic Drug Monitoring

IV. Pharmacokinetic Monitoring in Therapeutic Drug Monitoring

V. Pharmacokinetic/Pharmacodynamic (PK/PD) Antimicrobial Relationships

VI. Drug Interactions

7. Adverse Drug Reactions

I. Blood

II. Cardiovascular

III. Central Nervous System

IV. Skin

V. Gastrointestinal


VII. Renal/Genitourinary

VIII. Respiratory

IX. Hepatic

X. Ocular

XI. Musculoskeletal

XII. Hypersensitivity

XIII. Other

8. Recommended Antimicrobial Prophylaxis for Selected Infectious Agents and Conditions

9. Antimicrobial Desensitization Protocols

I. Penicillin

II. Amoxicillin

III. Cephalosporins

IV. Trimethoprim/Sulfamethoxazole (TMP/SMX) Oral

V. Fluoroquinolone

VI. Vancomycin

VII. Aminoglycosides

VIII. Clindamycin

IX. Linezolid

X. Darunavir

10. Formulary