Handbook of the Biology of Aging

Edited by

  • Matt Kaeberlein, University of Washington, Seattle, WA, USA
  • George Martin, University of Washington, Seattle, WA, USA

Capturing the rapid progress in the research of aging, the completely revised Eighth Edition of Handbook of the Biology of Aging provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, and presents new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transciptomic, proteomic, and metabolomics methodologies applied to aging related problems. Other new topics include: longevity pathways and interventions that modulate aging; innovative new tools that facilitate systems-level approaches to aging research; the mTOR pathway and its importance in age-related phenotypes; new strategies to pharmacologically modulate the mTOR pathway to delay aging; the importance of sirtuins and the hypoxic response in aging; how various pathways interact within the context of aging as a complex genetic trait; and whether interventions that increase lifespan also improve healthspan. Handbook of the Biology of Aging presents a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions.

The Handbook of the Biology of Aging, 8th edition, is part of the Handbooks of Aging series, including the Handbook of the Psychology of Aging and the Handbook of Aging and the Social Sciences, also in their 8th editions.

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Clinicians, researchers, and students in gerontology, developmental psychology, psychiatry, biology, and other related health care professions tasked with caring for the aging population


Book information

  • Published: September 2015
  • ISBN: 978-0-12-411596-5

Table of Contents

  1. Understanding Aging Through Conserved Longevity Pathways (New)
  2. Role of the somatotropic Axis in Mammalian Aging
  3. Mitochondria in aging: Dysfunction (new)
  4. Aging of Stem Cells: Intrinsic Changes and Environmental Influences
  5. Telomeres and Telomere Dysfunction in Aging
  6. mTOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species (new)
  7. Sirtuins in Aging and Age-Related Diseases
  8. Protein Homeostasis and Aging
  9. Genetics of Human Aging
  10. Calorie Restriction in Nonhuman and Human Primates (new)
  11. Terminal Weight Loss, Frailty, and Mortality
  12. Human Brain Myelination Trajectories Across the Life Span: Implications for CNS Function and Dysfunction
  13. Aging and Adipose Tissue
  14. Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Intervention
  15. Aging and Insulin Secretion
  16. Cardiovascular Effects of Aging in Primates-Gender Differences
  17. Cerebral Vascular Dysfunction with Aging
  18. Pulmonary Function in Aging Humans
  19. Bone Aging (new)
  20. Age-Related Changes in Thermoreception and Thermoregulation
  21. Sex Differences in Longevity and Aging
  22. Inflammation in Aging Processes: An Integrative and Ecological Perspective
  23. Systems Biology Approaches to Understanding Aging (new)
  24. Evolutionary Biology of Aging (new)
  25. Epigenetic Control of Longevity (new)
  26. An Objective Appraisal of the Free Radical Theory of Aging
  27. Aging Research in 2014: Promise and Pitfalls (new)