The Flaviviruses: Structure, Replication and Evolution

Edited by

  • Thomas Chambers
  • Thomas Monath, 1

Series Editor:

  • Karl Maramorosch, Rutgers University, New Brunswick, NJ, USA
  • Aaron Shatkin, Center for Advanced Biotechnology and Medicine, Piscataway, NJ, USA
  • Frederick Murphy, University of Texas Medical Branch, Galveston, USA

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase.
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Virologists, molecular epidemologists, clinicians and public health specialists, immunologists, and researchers in vaccine development


Book information

  • Published: December 2003
  • ISBN: 978-0-12-039859-1


"...the chapters are well written, and the editors have ensured continuity of a high standard of writing throughout the set...Given the wealth of information, with contributions by over 60 authors, The Flavaviruses, really is an essential series of books that belongs on every arbovirologists’ bookshelf." -Stephen Higgs, Ph.D., University of Texas Medical Branch, U.S., (2004)

Table of Contents

Taxonomy of the virus family FlaviviridaeStructure and replicationMolecular Biology of the FlavivirusesFlavivirus Structure and Membrane FusionKunjin RNA replication and applications of Kunjin repliconsAntigenic structure of flavivirus Proteins5' and 3' non-coding regions in flavivirus RNAManipulation of Cell Surface Macromolecules by FlavivirusesFlavivirus evolutionOrigins, Evolution and vecto/host cp-adaptations within the genus FlavivirusMicroevolution and virulence of dengue viruses