The Enzymes

Protein Methyltransferases

Edited by

  • Fuyuhiko Tamanoi, University of California, Los Angeles, USA
  • Steven Clarke, Department of Chemistry and Biochemistry, University of California Los Angeles, USA

Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.
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Biochemists, cell biologists, molecular biologists, biophysicists, and microbiologists


Book information

  • Published: June 2006
  • ISBN: 978-0-12-122725-8

Table of Contents

The Enzymes, Volume 24 Table of ContentsProtein methyltransferasesPart I: Overview of Protein Methyltransferases1. Protein methyltransferases: Their distribution among the five structural classes of AdoMet-dependent methyltransferasesPart II: Modification of Lysine and Arginine Residues in Signal Transduction, Transcription Translation, and Other Functions2. The family of protein arginine methyltransferases3. Diverse roles of protein arginine methyltransferases4. Structure of protein arginine methyltransferases5. Methylation and demethylation of histone Arg and Lys residues in chromatin structure and function6. Structure of SET domain protein lysine methyltransferases7. Non-histone protein lysine methyltransferases - structure and catalytic roles8. Demethylation pathways for histone methyllysine residuesPart III: Biological Regulation by Protein Methyl Ester Formation9. Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt), a key enzyme in CaaX processing10. Genetic approaches for understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins11. Reversible methylation of protein phosphatase 2A12. Reversible methylation of glutamate residues in the receptor proteins of bacterial sensory systemsPart IV: Recognition of Damaged Proteins in Aging by Protein Methyltransferases13. Protein L-isoaspartyl, D-aspartyl O-methyltransferases:catalysts for protein repairPart V: Modification of Proteins by Methylation of Glutamine and Asparagine Residues14. Modification of glutamine residues in proteins involved in translation15. Modification of phycobiliproteins at asparagine residuesPart VI: Inhibition of Metyltransferases by Metabolites16. Inhibition of mammalian protein methyltransferases by 5'-methylthioadenosine (MTA): A mechanism of action of dietary SAMe?