The EGF Receptor Family book cover

The EGF Receptor Family

Biologic Mechanisms and Role in Cancer

The enormity of the literature on growth factors, plus the breadth of the biological disciplines and technical expertise required prohibits a comprehensive review by even a multi-disciplinary panel of authors. To provide an alternative that is feasible for authors and digestible by readers, this review compendium consists of a collection of articles, each covering an aspect of teh ErbB/EGF field. This compilation features articles on growth factor ligands, neuregulins, and individual receptors. The second part of the book concentrates on the biological context of the ErbB receptors, particularly in mammary development and in cancer. It concludes with a discussion of the genetic systems that have enabled significant advances in research in this area.

Audience
Cancer researchers, oncologists, cell biologists, pharmacologists, neurologists, and biochemists.

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Published: December 2003

Imprint: Academic Press

ISBN: 978-0-12-160281-9

Contents


  • Introduction

    EGF Receptor Ligands

    Neuregulins: Functions, Forms, and Signaling Strategies

    Epidermal Growth Factor Receptor: Mechanisms of Activation and Signaling

    The Deaf and Dumb: The Biology of ErbB-2 and ErbB-3

    ErbB-4: Mechanism of Action and Biology

    Trafficking of the ErbB Receptors and Its Influence on Signaling

    Erbbs in Mammary Development

    The ErbB Receptors and their Role in Cancer Progression

    Ligand-Independent Oncogenic Signaling by the Epidermal Growth Factor Receptor: V-ErbB as a Paradigm

    ErbB-Targeted Therapeutic Approaches in Human Cancer

    Mechanism of Action of erbB Tyrosine Kinase Inhibitors

    Signaling by the Drosophila Epidermal Growth Factor Receptor Pathway during Development

    The Epidermal Growth Factor System in Caenorhabaditis Elegans


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