The EGF Receptor Family

Biologic Mechanisms and Role in Cancer

Edited by

  • Graham Carpenter, Vanderbilt University, Nashville, TN, U.S.A.

The enormity of the literature on growth factors, plus the breadth of the biological disciplines and technical expertise required prohibits a comprehensive review by even a multi-disciplinary panel of authors. To provide an alternative that is feasible for authors and digestible by readers, this review compendium consists of a collection of articles, each covering an aspect of teh ErbB/EGF field. This compilation features articles on growth factor ligands, neuregulins, and individual receptors. The second part of the book concentrates on the biological context of the ErbB receptors, particularly in mammary development and in cancer. It concludes with a discussion of the genetic systems that have enabled significant advances in research in this area.
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Audience

Cancer researchers, oncologists, cell biologists, pharmacologists, neurologists, and biochemists.

 

Book information

  • Published: December 2003
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-160281-9


Table of Contents


Introduction

EGF Receptor Ligands

Neuregulins: Functions, Forms, and Signaling Strategies

Epidermal Growth Factor Receptor: Mechanisms of Activation and Signaling

The Deaf and Dumb: The Biology of ErbB-2 and ErbB-3

ErbB-4: Mechanism of Action and Biology

Trafficking of the ErbB Receptors and Its Influence on Signaling

Erbbs in Mammary Development

The ErbB Receptors and their Role in Cancer Progression

Ligand-Independent Oncogenic Signaling by the Epidermal Growth Factor Receptor: V-ErbB as a Paradigm

ErbB-Targeted Therapeutic Approaches in Human Cancer

Mechanism of Action of erbB Tyrosine Kinase Inhibitors

Signaling by the Drosophila Epidermal Growth Factor Receptor Pathway during Development

The Epidermal Growth Factor System in Caenorhabaditis Elegans