The Cytokine Handbook, Two-Volume Set

Edited by

  • Angus Thomson, Departments of Surgery and Immunology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA
  • Michael Lotze, Departments of Surgery and Bioengineering, University of Pittsburgh Cancer Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics.
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Research level Immunologists, Pathologists, Cell and Cancer Biologists, Biochemists and Molecular Biologists. Clinicians and Clinical Researchers. Also major market in Pharmaceutical and Biotech Industry. Very significant bulk sales potential. (NB Reachable with use of BiomedSource)


Book information

  • Published: April 2003
  • ISBN: 978-0-12-689663-3


"Thompson and Lotze are to be commended for compiling this comprehensive work...The editors and authors should be commended for this very difficult task in this rapidly advancing field. There are excellent chapters on cytokine genetics, chemokine nomenclature, and the basic biology of each of the cytokines." -ASM NEWS (April 2004)

Table of Contents

Volume 1Preface ForewardSection I Basic Cytokine Biology 1 Cytokines Overview2 Cytokine Genetics 3 The Phylogeny of Cytokines 4 Cytokine Signalling Section II The Cytokines and ChemokinesSubsection A. The Hematopoietin Family Members5 Growth Hormone and its Receptors6 Prolactin 7 Erythropoietin 8 Interleukin 2 9 Interleukin 3 10 Interleukin 4 11 Interleukin 5 12 Interleukin 6 13 Interleukin 7 14 Interleukin 9 15 Interleukin 11 16 Interleukin 12 Family: IL-12 17 Interleukin 13 18 Interleukin 15 and Interleukin 21 19 Interleukin 16 20 Interleukin 17 21 Granulocyte-Macrophage 22 Granulocyte Colony-Stimulating Factor and its Receptor 23 M-CSF Subsection B. The Interferon Family Members 24 Type I Interferons 25 Interferon-g 26 Interleukin 10 27 Interleukins 19, 20, 22, 24 and 26 Volume II. Subsection C. The beta trefoil cytokines28 Interleukin 1 a and b 29 Interleukin 1 Receptor Antagonist 30 Novel Interleukin-1 Homologues 31 Interleukin 18 32 The Fibroblast Growth Factors 33 The Hepatocyte Growth Factor The HGF Receptor, MET 34 Toll-like Receptors: The Origins of Inflammation 35 Lymphotoxins 36 Tumor Necrosis Factor 37 TRAIL/apo2L 38 RANK-L : Receptor Activator of NF-kB Ligan39 CD95L/FasL its receptor CD95 (APO-1/Fas)40 HMGB-1/Amphoterin 41 EGF Family Ligand 42 FLT3 Ligand 43 Stem Cell Factor 44 Vascular Endothelial Growth Factor 45 Macrophage Migration Inhibitory Factor (MIF)46 Interleukin-8 and other CXC Chemokines 47 C-C Chemokines 48 Fractalkine-A Cell Surface Chemokines 49 Transforming Growth Factor b 50 Inhibin/Activin Family 51 Bone Morphogenic Proteins Section III. Clinical Application of Cytokines and Cytokine Inhibition52 Autoimmunity and Cytokines: Pathogenesis and Therapy 53 Cytokines and Cancer Caligiuri54 Interferon alpha: biology, pharmacology, and therapy for chronic viral hepatitis 55 Haemopoietic Cytokines 56 Antiangiogenesis 57 Transplantation 58 Cytokines and Asthma 59 Cytokine Gene Transfer 60 Antisense Therapy 61 Assays for Cytokines