The Comprehensive Sourcebook of Bacterial Protein Toxins

Edited by

  • Joseph Alouf, Institute Pasteur de Lille, France
  • Michel Popoff, D.V.M., Ph.D, CNR Anaerobies et Botulisme, Unite Bacteries anaerobies et Toxines, Institut Pasteur, FRANCE


  • Joseph Alouf, Institute Pasteur de Lille, France
  • Daniel Ladant, Ph.D, PhD, Director of Research at French CNRS (National Center for Scientific Research) and head of the Biochemistry of Macromolecular Interactions unit at Institut Pasteur, Paris, France
  • Michel Popoff, D.V.M., Ph.D, CNR Anaerobies et Botulisme, Unite Bacteries anaerobies et Toxines, Institut Pasteur, FRANCE

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.
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Researchers, Academics, Graduate Students and PhD's in general microbiology, clinical microbiology and infectious disease


Book information

  • Published: December 2005
  • ISBN: 978-0-12-088445-2


“The title of this book says it all - this volume is encyclopedic, thorough, and as complete as any book of this type could be. …This book is a pièce de résistance. The editors are to be congratulated on producing a revised edition with vitality. They have successfully met all of the challenges posed in knitting diverse contributions together. The Comprehensive Sourcebook of Bacterial Protein Toxins will be an authoritative reference work for many years. Every medical school and university library must have a copy. For the individual purchaser, it will be a worthwhile investment and a treasure trove of information.” - Cyril J. Smith, Trinity College Dublin, Ireland for CLINICAL INFECTIOUS DISEASES (Sept 2006) "Doody's 3 Star Review: This book presents an overview of current approaches to protein structure prediction. Beginning with very basic concepts, there is a transition to modern methods with a strong (and logical) emphasis on computational approaches...This book offers a comprehensive introduction to the techniques commonly employed in [the] field...This is a concise, well written overview of the field. More technical manuals are available and there is a great deal of primary literature. Nonetheless, this book is of substantial value to younger scientists." - Eugene A Davidson, PhD, Georgetown University School of Medicine (2006)

Table of Contents

IntroductionA 116-year story of bacterial protein toxins (1888-2004): From 'diphtheritic poison' to molecular toxinology Evolutionary aspects of toxin-producing bacteria Mobile genetic elements and pathogenicity islands encoding bacterial toxinsRegulation systems of toxin expressionToxin secretion systemsIntracellular trafficking of bacterial protein toxinsTranslocation of bacterial protein toxin into the cytosolBacterial toxins and virulence factors targeting the actin cytoskeleton and intracellular junctionsBacterial toxins and mitochondriaToxins activating RHO GTPases and exploiting the cellular ubiquitin/proteasome machineriesToxin receptorsMolecular, functional and evolutionary aspects of ADP-ribosylating toxinsDiphtheria toxin Attack of the nervous system by clostridial toxins: Physical findings, cellular and molecular actionsUptake and transport of clostridial neurotoxinsBacillus anthracis toxinsLarge clostridial cytotoxins modifying small GTPases Bordetella protein toxins Vibrio Cholerae and Escherichia Coli thermolabile enterotoxinThe Shiga toxins: Properties and action on cellsHelicobacter pylori vacuolating toxinPasteurella multocida toxinCytolethal distending toxinsPseudomonas aeruginosa toxinsEscherichia coli heat- stable enterotoxin bParadigms and classification of bacterial membrane -damaging toxinsMembrane damaging and cytotoxic phospholipasesBacteroides fragilis toxinsStructure and mode of action of RTX cytolysinsGenetics and phylogeny of RTX cytolysinsThe family of two-component cytolysins of Serratia and other bacteriaAlpha-helix and Beta-barrel pore-forming toxins (leucocidins, alpha-, gamma- and delta-cytolysins) of Staphylococcus aureusAerolysin and related Aeromonas toxinsClostridium septicum pore-forming alpha-toxinClostridium perfringens epsilon toxinRepertoire and general features of the family of cholesterol-dependent cytolysinsComparative three-dimensional structure of cholesterol-dependent cytolysinsPerfringolysin O and Intermedilysin: mechanisms of pore formation by the cholesterol-dependent cytolysinsPneumolysin: structure, function and role in diseaseListeriolysinEnterococcus faecalis cytolysin toxinStreptolysin S: one of the most potent and elusive of all bacterial toxinsThe group B streptococcal beta-haemolysin/cytolysinHaemolysins of Vibrio cholerae and other Vibrio speciesClostridium perfringens enterotoxinBacillus cereus enterotoxins, bi- and tri-component cytolysins and other haemolysinsUropathogenic Escherichia coli cytolysinsEscherichia coli, Vibrio and Yersinia species heat-stable enterotoxinsWhat are superantigens ?Staphylococcal superantigens and the diseases they causeStreptococcal superantigenic toxinsSuperantigenic toxin of Yersinia pseudotuberculosisComparative three-dimensional structure of bacterial superantigenic toxinsInduction and modulation of inflammatory networks by bacterial protein toxinsClostridial toxins in the pathogenesis of gas gangreneStaphylococcal exfoliative toxinsMedical applications of botulinum neurotoxinsBacterial protein toxins as food poisons Engineering of bacterial toxins for research and medicineEngineered bacterial toxin vaccines and adjuvantsToxins as toolsBacterial protein toxins as biological weaponsINDEX