The Clostridia

Molecular Biology and Pathogenesis

Edited By

  • Julian Rood, Monash University, Melbourne, Australia
  • Bruce McClane, University of Pittsburgh, Pennsylvania, U.S.A.
  • J. Songer, University of Arizona, Tucson, U.S.A.
  • Richard Titball, Defence Evaluation and Research Agency, Porton Down, CBD Salisbury, Wiltshire, U.K.


Postgraduates and researchers in microbiology, microbial toxins, anaerobes, microbial genetics, toxicology, medicine and veterinary science specialists in infectious diseases, medical and veterinary school libraries, professionals in the pharmaceuticals/diagnostics industries, and food microbiologists.


Book information

  • Published: April 1997
  • ISBN: 978-0-12-595020-6


"...the authors have succeeded in providing a state-of-the-art reference work that describes the latest details of the genetics, molecular biology, biochemistry, and disease mechanisms of clostridia... the book is well organized, well written and edited by authorities renowned for their work with clostridia... I highly recommend this book to anyone seeking to understand the current views regarding the pathogenesis of clostridial Disease."

"The editors have been successful in their attempts to solicit an outstanding group of contributing authors who have written comprehensive reviews on their respective topics. This book should be viewed as a timely and unique resource covering the wide breath of applied and basic research efforts directed against understanding the biology and molecular pathogenesis of clostridial infections."
"It is an impressive publication, clearly presented, well-illustrated and shows the extent of detailed knowledge now available on the Clostridia... The book would be a very valuable addition to university libraries and to the shelves of those who have a focus or interest in the pathogenesis of infectious diseases."

Table of Contents

General Biology:E. Stackebrandt and F.R. Rainey, Phylogenetic Relationships.R.G. Labbe and N-J. Shih, Physiology of Sporulation of Clostridia.Genome Organisation and Molecular Genetics:E.A. Johnson, Extrachromosomal Virulence Determinants in the Clostridia.S.T. Cole, Structure, Genetic Organization and Evolution of the Genome of Clostridium Perfringens.J.I. Rood, Genetic Analysis in Clostridium Perfringens.D. Lyras and J.I. Rood, Transposable Genetic Elements and Antibiotic Resistance Determinants of Clostridium Perfringens and Clostridium Difficile.Clostridia in Clinical Practice:S.S. Arnon, Human Tetanus and Human Botulism.S. Johnson and D.N. Gerding, Enteroxaemic Infections.D.L. Stevens, Necrotizing Clostridial Soft Tissue Infections.J.G. Songer, Clostridial Diseases of Animals.Pathogenesis of Infections:A.E. Bryant and D.L. Stevens, The Pathogenesis of Gas Gangrene.G. Lawrence, The Pathogenesis of Enteritis Necroticans. Membrane Active Toxins and Enzymes:R.K. Tweten, The Thiol Activated Clostridial Toxins. R.W. Titball, Clostridial Phospholipases.S.E.C. Leary and R.W. Titball, The Clostridium Perfringens beta-Toxins.J.D. Ballard and R.K. Tweten, Clostridium Septicum alpha-Toxin. Neurotoxins:I. Henderson, T. Davis, M. Elmore, and N.P. Minton, The Genetic Basis of Toxin Production in Clostridium Botulinum and Clostridium Relam.G. Schiavo and C. Montecucco, The Structure and Mode of Action of Botulinum and Tetanus Toxins. Enterotoxins:J.F. Kokai-Kun and B.A. McClane, The Clostridium Perfringens Enterotoxin.R.J. Carmen, S. Perelle, and M.R. Popoff, Binary Toxins from Clostridium Spiroforme and Clostridium Perfringens.J.S. Moncrief, D.M. Lyerly, and T.D. Wilkins, Molecular Biology of the Clostridium Difficile Toxins.K. Aktories, J. Selzer, F. Hofmann and I. Just, Molecular Mechanism of Action of Clostridium Difficile Toxins A and B. Other Toxins and Extracellular Enzymes:A. Okabe and S.T. Cole, Extracellular Enzymes from Clostridium Perfringens and Clostridium Histolyticum that Damage Connective Tissue.P. Roggentin and R. Schauer, Clostridial Sialidases.D. Payne and P. Oysten, The Clostridium Perfringens beta-Toxin.Regulation of Virulence:T. Shimizu, A. Okabe, and J.I. Rood, Regulation of Toxin Production in Clostridium Perfringens.S.B. Melville, R.E. Collie, and B.A. McClane, Regulation of Enterotoxin Production in Clostridium Perfringens.Control and Diagnosis:J.G. Songer, Molecular and Immunological Methods for the Diagnosis of Clostridial Infections.J.E. Brown and E.D. Williamson, Molecular Approaches to Novel Vaccines for the Control of Clostridial Toxaemias and Infections.Index.