Cerebrospinal fluid (CSF) functions to bathe the brain and spinal cord and is vital for the maintenance of fluid homeostasis within the central nervous system (CNS). The production of CSF by the choroid plexus is tightly regulated, providing the necessary nutrients and removing waste that may compromise the normal homeostasis of the CNS. Though growth factors and neuropeptide hormones produced and secreted by the choroid plexus are known to play critical roles in CNS homeostasis, the choroid plexus and CSF have been one of the most understudied tissues in neuroscience.
Recent work has begun to elucidate how the choroid plexus and CSF regulate development and disease in ways that extend far beyond traditional neurobiology roles. This book presents novel and exciting findings in the area of the choroid plexus and CSF in brain development and introduces its link to multiple disease disciplines, including cancer biology and neurodegeneration. Each chapter is written by an expert in his/her field and provides a comprehensive review of the anatomy, development, structure, and function of the choroid plexus and CSF in the nervous system, with particular focus on multiple disease disciplines, including primary brain tumours, metastases, Multiple Sclerosis, and Alzheimerâs Disease. This book provides a link between the choroid plexus, the clinical problems arising from its dysfunction, and investigational approaches and techniques that will help foster future research with high translational value.
The Choroid Plexus and Cerebrospinal Fluid 1e
combines new and established work to allow for cross-disciplinary discussion and showcase newfound excitement surrounding the choroid plexus and CSF. This book is of great utility to neuroscientists interested in biological questions about cancer, Multiple Sclerosis, Alzheimerâs, choroid plexus, or CSF research, and especially for researchers looking to expand their research into later stages of their disease of interest, such as metastasis. The focus on the choroid plexus provides a practical resource on modeling clinical issues influenced by this brain region for researchers from students to principal investigators. No other resource is currently available which addresses these issues in this fashion, and so this volume fills a much needed niche in the literature.