The Choroid Plexus and Cerebrospinal Fluid

Emerging Roles in CNS Development, Maintenance, and Disease Progression

Edited by

  • Josh Neman, Department of Neurological Surgery, Keck School of Medicine, USC, Los Angeles, CA, USA
  • Thomas C. Chen, Department of Neurological Surgery, Keck School of Medicine, USC, Los Angeles, CA, USA

The Choroid Plexus and Cerebrospinal Fluid combines new and established work to allow for cross-disciplinary discussion and showcase newfound excitement surrounding the choroid plexus and cerebrospinal fluid (CSF). This book is of great utility to neuroscientists interested in biological questions about cancer, Multiple Sclerosis, Alzheimer’s, choroid plexus, or CSF research, and especially for researchers looking to expand their research into later stages of their disease of interest, such as metastasis. No other resource is currently available which addresses these issues in this fashion. The focus on the choroid plexus provides a practical resource on modeling clinical issues influenced by this brain region for researchers from students to principal investigators.
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Graduate students in biological and biomedical sciences, post-doctoral students and fellows, as well as all researchers and clinicians seeking a resource on the interactions of choroid plexus, cerebrospinal fluid during normal development, maintenance of brain microenvironment and neurodegenerative diseases (Multiple Sclerosis and Alzheimer’s Disease) and brain tumors (primary and metastatic).


Book information

  • Published: October 2015
  • ISBN: 978-0-12-801740-1

Table of Contents

1. Introduction to the Ventricular System and Choroid Plexus
   Tatsuhiro Fujii, Joshua Yousefzadeh, Michael Novel and Josh Neman

2. Development of brain ventricles and choroid plexus
   Ellen M. Carpenter

3. Cytoarchitecture of choroid plexus, CSF, and role in blood-brain-barrier
   Thomas C. Chen and Florence Hoffman

4. Towards an artificial choroid plexus, concept and clinical implications
   Thomas Brinker and John Morrison

5. Choroid Plexus Tumors
   Sean A. Grimm and Marc C. Chamberlain

6. Role of Blood Brain Barrier, Choroid Plexus, and Cerebral Spinal Fluid in Extravasation and Colonization of Brain Metastases
   Cecilia Choy and Josh Neman

7. The Role of the Choroid Plexus in the Pathogenesis of Multiple Sclerosis
   Vahan Martirosian and Josh Neman

8. The Choroid Plexus and Cerebrospinal Fluid system: roles in neurodegenerative diseases
   Jérôme Badaut and Jean-François Ghersi-Egea

9.  Modeling the blood-CSF barrier and  drug delivery into the CNS
   Thomas C. Chen and Axel Shönthal