The Central Nervous System Control of Respiration

Edited by

  • Gert Holstege, University Medical Center Groningen, The Netherlands
  • Caroline M. Beers, University Medical Center Groningen, The Netherlands
  • Hari H. Subramanian, The University of Queensland, Australia

Respiration is one of the most basic motor activities crucial for survival of the individual. It is under total control of the central nervous system, which adjusts respiratory depth and frequency depending on the circumstances the individual finds itself. For this reason this volume not only reviews the basic control systems of respiration, located in the caudal brainstem, but also the higher brain regions, that change depth and frequency of respiration. Scientific knowledge of these systems is crucial for understanding the problems in the many patients suffering from respiratory failure.
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This volume not only provides essential information for neuroscientists involved in respiration research, but also for clinicians treating patients with respiratory problems.


Book information

  • Published: May 2014
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-63274-6

Table of Contents

Rhythmic Bursting in the Pre-B├Âtzinger Complex: Mechanisms and Models
Effects of Glycinergic Inhibition Failure on Respiratory Rhythm and Pattern Generation
Morphological Characterization of Respiratory Neurons in the pre-B├Âtzinger Complex
Cytoarchitecture and CO2 Sensitivity of Phox2b-Positive Parafacial Neurons in the Newborn Rat Medulla
Contributions of the pre-B├Âtzinger Complex and the K├Âlliker-Fuse Nuclei to Respiratory Rhythm and Pattern Generation in Awake and Sleeping
The Integrative Role of the Sigh in Psychology, Physiology, Pathology and Neurobiology
Mechanism of Sympathetic Activation and Blood Pressure Elevation in Humans and Animals following Acute Intermittent Hypoxia
Effect of Chronic Intermittent Hypoxia on the Reflex Recruitment of the Genioglossus during Airway Obstruction in the Anaesthetized Rat
Peptides, Serotonin and Breathing: The Role of the Raphe in the Control of Respiration
Cardiorespiratory Coupling: Common Rhythms in Cardiac, Sympathetic and Respiratory Activities
Serotonin Neurons and Central Respiratory Chemoreception: Where are we now?
Bidirectional Plasticity of Pontine Pneumotaxic Post-Inspiratory Drive: Implication for a Pontomedullary Respiratory Central Pattern Generator
Sleep-Wake Control of the Upper Airway by Noradrenergic Neurons, with and without Intermittent Hypoxia
Affective Brain Areas and Sleep Disordered Breathing
The Neural Control of Human Inspiratory Muscles
Convergence of Pattern Generator Outputs on a Common Mechanism of Diaphragm Motor Unit Recruitment
The Peripheral Actions of the Central Neuropeptide Somatostatin on Control of Breathing: Effect on Metabolic Rate and Chemoreflex Responses in Humans
Control of Blood Pressure, Micturition and Respiration via the Human Brain using Neurosurgery
Where is the Rhythm Generator for Emotional Breathing?
The Periaqueductal Gray Controls Brainstem Emotional Motor Systems Including Respiration