The Autoimmune Diseases

Edited by

  • Ian Mackay, Monash University, Clayton, Victoria, Australia
  • Noel R Rose, Director, Center for Autoimmune Disease Research, Bloomberg School of Public Health, John's Hopkins University, Baltimore, MD, USA

Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors.
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Audience

Basic and clinical scientists working in immunology, rheumatology and autoimmune diseases

 

Book information

  • Published: December 2013
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-384929-8

Reviews

"...incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders."--Anticancer Research, February 2015

"This authoritative book on autoimmune diseases is useful for clinicians and basic scientists alike. It is easy to read but is also useful as a reference. The authors provide an extensive overview of autoimmunity, ranging from basic mechanisms of disease to clinical features. Rating - 4 Stars"--Doody.com, August 2014

"...edited by Noel R. Rose and Ian R. Mackay, widely recognized experts in autoimmunity and its pathophysiological and clinical aspects. This thoughtfully updated new edition takes into consideration important developments in basic and clinical science. This book will be a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune diseases, to scientists who want to follow developments in the field, and to all those who enjoyed the previous edition."--Martha M. Eibl, M.D. for NEW ENGLAND JOURNAL OF MEDICINE, Jan 2006




Table of Contents

IMMUNOLOGIC BASIS OF AUTOIMMUNITYAUTOIMMUNITY: A HISTORY OF THE EARLY STRUGGLE FOR RECOGNITIONSTRUCTURAL AND FUNCTIONAL ASPECTS OF THE INNATE AND ADAPTIVE SYSTEMS OF IMMUNITYGENERAL FEATURES OF THE AUTOIMMUNE DISEASESANTIGEN PRESENTATION, DENDRITIC CELLS AND AUTOIMMUNITYMHC COMPLEX AND AUTOIMMUNITYT CELLS AND AUTOIMMUNITYROLE OF TH1 AND TH2 CELLS IN AUTOIMMUNITYTOLERANCE AND AUTOIMMUNITY – T CELLSREGULATORY T CELLSPEPTIDE-BASED INSTRUCTION OF SUPPRESSOR COMMITMENT IN NAÏVE T CELLSB CELLS AND AUTOIMMUNITYMEMORY B CELL DEVELOPMENTTOLERANCE AND AUTOIMMUNITY – B CELLSGENERATION OF T CELL ANTIGENIC DETERMINANTS IN AUTOIMMUNITY AND THEIR RECOGNITIONAPOPTOTIC CELLS AS A SOURCE OF AUTOANTIGENSEFFECTOR MECHANISMS OF AUTOIMMUNITY: ANTIBODIES, IMMUNE COMPLEXESFUNCTIONAL EFFECTS OF ANTIBODIESADHESION MOLECULES AND CHEMOATTRACTANTS: RELEVANCE TO THE PATHOGENESIS AND TREATMENT OF AUTOIMMUNE DISEASESSIGNALING PATHWAYS IN T AND B LYMPHOCYTESGENETICS AND AUTOIMMUNITY: ROLE OF HLA IN AUTOIMMUNE DISEASESGENETICS AND AUTOIMMUNITY - NON-MHCINFECTIONS, IMMUNITY AND AUTOIMMUNITYNON-INFECTIOUS ENVIRONMENTAL AGENTS AND AUTOIMMUNITYVACCINES AND AUTOIMMUNE DISEASESSEX, PREGNANCY AND AUTOIMMUNITYMULTISYSTEM DISEASESANIMAL MODELS FOR AUTOIMMUNE DISEASESYSTEMIC LUPUS ERYTHEMATOSUS, CHRONIC CUTANEOUS LUPUS, AND MIXED CONNECTIVE TISSUE DISEASETHE IMMUNOLOGY OF SYSTEMIC LUPUS ERYTHEMATOSUSSYSTEMIC SCLEROSIS- SCLERODERMAANTIPHOSPHOLIPID SYNDROMESJÖGREN’S SYNDROME (AUTOIMMUNE EPITHELITIS)RHEUM ATOID ARTHRITISSPONDYLOARTHRITIS AND CHRONIC IDIOPATHIC ARTHROPATHIESPOLYMYOSITIS AND DERMATOMYOSITIS*ENDOCRINE AND RELATED DISEASESTHYROID DISEASETYPE 1 DIABETESADRENALITISPOLYENDOCRINE SYNDROMESAUTOIMMUNE GASTRITIS AND PERNICIOUS ANEMIAAUTOIMMUNE HYPOPHYSITIS BLOOD DISEASESAUTOIMMUNE HEMOLYTIC ANEMIAAUTOIMMUNE THROMBOCYTOPENIC PURPURAAUTOIMMUNE NEUTROPENIAACQUIRED APLASTIC ANEMIACLOTTING DISORDERSNEUROLOGIC DISEASESMULTIPLE SCLEROSISPERIPHERAL NEUROPATHIESMYASTHENIA GRAVIS AND ANTI-RECEPTOR DISEASES OF THE NERVOUS SYSTEMUVEITISINNER EAR DISEASEINTESTINAL, HEPATIC, AND PANCREATIC DISEASESCELIAC DISEASEINFLAMMATORY BOWEL DISEASES: ULCERATIVE COLITIS AND CROHN’S DISEASECHRONIC HEPATITISPRIMARY BILIARY CIRRHOSISPRIMARY SCLEROSING CHOLANGITISAUTOIMMUNE PANCREATITISCUTANEOUS DISEASESBULLOUS SKIN DISEASES: PEMPHIGUS VULGARIS AND OTHER TYPES OF PEMPHIGUSNON-BULLOUS SKIN DISEASES: ALOPECIA, PSORIASIS, VITILIGO, URTICARIAUROGENITAL DISEASESKIDNEY: GOODPASTURE’S DISEASE, LUPUS NEPHRITIS, ANCA-ASSOCIATED GLOMERULONEPHRITISAUTOIMMUNE ORCHITIS AND MALE INFERTILITYOOPHORITISCARDIOVASCULAR AND PULMONARY DISEASESRHEUMATIC HEART DISEASEMYOCARDITIS AND DILATED CARDIOMYOPATHYATHEROSCLEROSIS: AUTOIMMUNITY TO HEAT-SHOCK PROTEINSNECROTIZING ARTERITIS AND SMALL VESSEL VASCULITISVASCULITISIDIOPATHIC BRONCHIOLITIS OBLITERANS, IDIOPATHIC PULMONARY FIBROSIS, AND THE AUTOIMMUNE DISORDERS OF THE LUNGNEOPLASIA AND AUTOIMMUNITYPARANEOPLASTIC DISEASES – AUTOIMMUNE RESPONSES TO TUMOR ANTIGENSLYMPHOMA AND AUTOIMMUNE DISEASEAPOPTOSIS AND AUTOIMMUNITY -LYMPHOPROLIFERATIVE SYNDROMESMISCELLANEOUSCAMEOSDIAGNOSIS, PREVENTION, AND THERAPYAUTOANTIBODY ASSAYS, TESTING AND STANDARDIZATIONT-CELL ASSAYSPREDICTION OF AUTOIMMUNE DISEASETHE PREVENTION OF AUTOIMMUNE DISEASE: TYPE 1 DIABETES AS A PARADIGMEMERGING THERAPIES IN AUTOIMMUNE DISEASESEPILOGUE - ADVOCATUS DIABOLI