The Aging Skeleton

Edited by

  • Clifford Rosen, The Jackson Laboratory, Bar Harbor, Maine, U.S.A.
  • Julie Glowacki, Brigham and Women's Hospital and Massachusetts General Hospital, Harvard Medical School and Harvard School of Dental Medicine, Boston, Massachusetts, U.S.A.
  • John Bilezikian, Columbia University, New York, New York, U.S.A.

The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics.
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Researchers and academic clinicians, students, and postdoctorates in bone/mineral metabolism, endocrinology, orthopedic, and gerontology research; pharmaceutical industry; contract labs.


Book information

  • Published: July 1999
  • ISBN: 978-0-12-098655-2

Table of Contents

General Aspects and Models of Aging:D. Nelson, Aging Through the Ages.S. Sherman, Aging in the Human Species.R.P. Heaney, Aging and Calcium Balance.D.N. Kalu, Whole Animal Models of Aging.L. Lipson, Humans.J. Glowacki, Cellular Models.Determinants of Peak Bone Mass; Maintenance of Peak Bone Mass:E. Seeman, Genetics.T. Lloyd, Nutritional.M. van der Meulen and D. Carter, Environmental/Mechanical.M. Warren, Hormonal Influences on the Establishment of Peak Bone Mass.N.H. Bell, Racial.D.T. Baran, Determinants of Maintenance of Bone Mass.Mechanisms of Age-Related Bone Loss:P. Robey, Cellular.M. Leboff and J. Glowacki, Sex Steroids.S.J. Silverberg and J.P. Bilezikian, Parathyroid Hormone.F.M. Gloth, Vitamin D.M. Horowitz and L. Raisz, Cytokines.S. Mohan, Growth Hormone/IGFs.P.H. Stern and P. Lakatos, Other Factors.J. Anderson, Nutritional.C.T. Rubin and J. Rubin, Constraints of Experimental Paradigms Used to Model the Aging Skeleton.Quantifiable Manifestations of Age-Related Bone Loss: M.L. Villa and D. Nelson, Racial/Ethnic Influences on Bone Loss.J. Compston, Histomorphometric.C. Mautalen, Densitometric.C. Gundberg, S. Robins and M. Seibel, Biochemical Dynamics.D. Burr and C.H. Turner, Biomechanical Measurements.Fractures: A Consequence of the Aging Skeleton:M.L. Bouxsein, Applications of Biomechanics to the Aging Human Skeleton.R.D. Wasnich, What is a Fragility Fracture?P.D. Ross, Epidemiology/Economics of Osteoporotic Fractures.M. Nevitt, Sites of Fracture-Spine, Hip, Colles, Other.M. August, L. Kaban, The Aging Maxillo-Facial Skeleton.D. Gold, Effects on the Quality of Life.T. Einhorn and Moffett, General Orthopedics Principles.R. Rizzoli, Nutritional and Supportive.P. Leong, Analgesic Management.Therapeutics:T. Thornhill and M. Winemaker, Complications of Prosthetic Replacements.M. Sinaki, The Shape and Size of an Osteoporotic Woman.D.P. Kiel, Prevention of Falls.R. Marcus and B. Beck, Physical Activity.R.L. Prince, Calcium.R. Lindsay and F. Cosman, Estrogen.E.S. Siris and D. Schussheim, SERMS.E.S. Orwoll, Androgens.S. Papapoulos, Biphosphonates.C. Waud and J. Stock, Calcitonin.A.B. Hodsman, Parathyroid Hormone.C.J. Rosen, Growth Hormone-IGF-1.D. Baylink, Fluoride.M. Favus, Vitamin D.