T Cell Subsets
Cellular Selection, Commitment and Identity
- H. Cantor, Dana Farber Cancer Institution, Boston, Massachussetts, U.S.A.
- Laurie Glimcher, Harvard School of Public Health, Boston, Massachussetts, U.S.A.
- Frederick Alt, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA
This first thematic issue, of the Advances in Immunology series, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a fundamental impact on a number of research fields -immunology, cell biology, hematology and stem cell research. All of these groups have a vested interest in comprehending issues such as stem cell self renewal, progenitor plasticity, lineage commitment and cellular identity. Immunologists have a special interest in the mechanisms that allow selection of a T cell repertoire whose members integrate genetic information for T cell receptor, co-receptor and specialized immunologic function, since this process lies at the core of adaptive immunity.T Cell Subsets is a timely and invaluable review for immunologists, cell biologists hematologists and stem cell researchers
Immunologists and infectious disease researchers