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Systems Biomedicine
Concepts and Perspectives
1st Edition - September 17, 2009
Editors: Edison T. Liu, Douglas A. Lauffenburger
Language: English
eBook ISBN:9780080919836
9 7 8 - 0 - 0 8 - 0 9 1 9 8 3 - 6
Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from co…Read more
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Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems.
Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon.
Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine
Provides precise and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable
Includes a thorough discussion of the applications of quantitative principles to biomedical problems
cell, molecular, and developmental biology, genetics/ genomics, mathematics, biotechnology, biological and chemical engineering, physiology, and bioinformatics researchers involved in systems biology studies; students of systems biology
I. Foundations of Systems Biology Genomic Technologies for Systems Biology Proteomic Technologies
II. Computational Modeling of Biological Systems Dynamic Systems Analysis Spatio-temoral Modeling of Cellular Systems High-level modeling of biological networks High-Performance Computing Modeling Software
III. Network Biology Protein Interaction Networks Signaling Networks with Modeling Strategies Protein networks in integrin-mediated adhesions Network Imaging RNAi networks
IV. Integrative Biology of Higher Biosystems Signal Processing and Integration During Development Systems Biology and Stem Cell Biology Application of immunologic modeling in drug discovery and development
V. Systems Medicine Applications Systems Pharmacology
No. of pages: 448
Language: English
Edition: 1
Published: September 17, 2009
Imprint: Academic Press
eBook ISBN: 9780080919836
EL
Edison T. Liu
Affiliations and expertise
Genome Institute of Singapore, Singapore
DL
Douglas A. Lauffenburger
Affiliations and expertise
Massachusetts Institute of Technology, Cambridge, MA, USA