Systemic Lupus Erythematosus
A Companion to Rheumatology
By- George Tsokos
- Caroline Gordon
- Josef Smolen, MD, Department of Internal Medicine, University of Vienna and Center for Rheumatic Diseases, Lainz Hospital, Vienna, Austria
This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment.
Audience
Rheumatologists
Hardbound, 608 Pages
Published: January 2007
Imprint: Mosby
ISBN: 978-0-323-04434-9
Contents
- Epidemiology and Diagnosis
1. Epidemiology
2. Disease Activity Measures
3. Disease Outcome
4. Quality of Life and Economic Aspects
Pathogenesis
1. Overview of the Pathogenesis of SLE
2. Genetics
3. Hormones
4. Immunoregulation T Cells, B cells, and cytokines.
5. Cell Surface Receptors ostimulation/BAFF/FcgR/TLRs)
6. Dendritic Cells
7. Apoptosis
8. Structure and Origin of Autoantibodies
9. Animal Models
10. Genetics of murine lupus
11. Infection and autoimmunity
Mechanisms of Tissue Damage
1. Complement
2. Immune complexes
3. Antibodies
a. ANA and standardization of antibody techniques
b. Anti-DNA
c. Anti-splicesomosal ab
d. Anti-Ro/La
e. Anti-Histone
f. APL
g. Anti-neuronal
4. PMNs
5. Mechanisms of renal damage
6. Mechanisms of vascular damage
7. Nitric Oxide
Clinical Aspects of the Disease
1. Constitutional Symptoms and Fatigue
2. Skin
3. Kidney
4. Heart
5. Lung
6. GI/liver/pancreas
7. Infections
8. Blood (anti-phospholipid syndrome)
9. Nervous System
10. Overlap Syndromes
11. Ophthalmic Manifestations
12. Pregnancy
13. Fertility
14. Neo-natal lupus
15. Hereditary and Malignant Lupus-like Diseases
Treatment of the Disease
1. Non-Steroidals Anti-Malarials and Statins
2. Steroid Treatment
3. Cytotoxic Drug Treatment including M.M.F
4. PAPS
5. New Treatments
