Systemic Lupus Erythematosus book cover

Systemic Lupus Erythematosus

A Companion to Rheumatology

This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find ‘one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment.


Hardbound, 608 Pages

Published: January 2007

Imprint: Mosby

ISBN: 978-0-323-04434-9


  • Epidemiology and Diagnosis

    1. Epidemiology

    2. Disease Activity Measures

    3. Disease Outcome

    4. Quality of Life and Economic Aspects


    1. Overview of the Pathogenesis of SLE

    2. Genetics

    3. Hormones

    4. Immunoregulation – T Cells, B cells, and cytokines.

    5. Cell Surface Receptors ostimulation/BAFF/FcgR/TLRs)

    6. Dendritic Cells

    7. Apoptosis

    8. Structure and Origin of Autoantibodies

    9. Animal Models

    10. Genetics of murine lupus

    11. Infection and autoimmunity

    Mechanisms of Tissue Damage

    1. Complement

    2. Immune complexes

    3. Antibodies

    a. ANA and standardization of antibody techniques

    b. Anti-DNA

    c. Anti-splicesomosal ab

    d. Anti-Ro/La

    e. Anti-Histone

    f. APL

    g. Anti-neuronal

    4. PMNs

    5. Mechanisms of renal damage

    6. Mechanisms of vascular damage

    7. Nitric Oxide

    Clinical Aspects of the Disease

    1. Constitutional Symptoms and Fatigue

    2. Skin

    3. Kidney

    4. Heart

    5. Lung

    6. GI/liver/pancreas

    7. Infections

    8. Blood (anti-phospholipid syndrome)

    9. Nervous System

    10. Overlap Syndromes

    11. Ophthalmic Manifestations

    12. Pregnancy

    13. Fertility

    14. Neo-natal lupus

    15. Hereditary and Malignant Lupus-like Diseases

    Treatment of the Disease

    1. Non-Steroidals – Anti-Malarials and Statins

    2. Steroid Treatment

    3. Cytotoxic Drug Treatment including M.M.F

    4. PAPS

    5. New Treatments


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