Synthetic Biology book cover

Synthetic Biology

Tools and Applications

Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems.

Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems.

Audience

Geneticists, molecular biologists, physicists, chemists, and bioengineers

Hardbound, 352 Pages

Published: May 2013

Imprint: Academic Press

ISBN: 978-0-12-394430-6

Reviews

  • "Chemical, biological, and biochemical engineers describe tools and methodologies developed for engineering biological systems at a wide range of levels, including molecular, pathway, network, whole cell, and multi-cell. They also explore practical applications of synthetic biology, a branch of genetic engineering that incorporates systems biology."--Reference and Research Book News, August 2013

    “The proposed book is exclusively focused on synthetic biology. It brings together the thought leaders in this emerging field, giving expert accounts and their opinions of special topics in synthetic biology…. This might be the first dedicated, edited book for synthetic biology.”--Dr. Qing Lin, State University of New York at Buffalo, Buffalo, NY, USA


Contents

  • Introduction
    Section I. Synthesis and engineering tools in synthetic biology
    Chapter 1. DNA synthesis
    Chapter 2. Protein engineering
    Chapter 3. Pathway engineering
    Chapter 4. Biological standardization

    Section II. Computational and theoretical tools in synthetic biology
    Chapter 5. Biocomplexity issues in synthetic biology
    Chapter 6. Computational protein design
    Chapter 7. Computer-Aided Design in Synthetic Biology
    Chapter 8. Computational tools for strain design

    Sections III. Applications in synthetic biology
    Chapter 9. Pathway/network level: design and applications of therapeutic genetic circuits 
    Chapter 10. Pathway/network level: production of drugs
    Chapter 11. Pathway/network level: synthesis of new fuels
    Chapter 12. Organism level: genome assembly
    Chapter 13. Multi-cell level: synthetic prey-predator system 

    Section IV. Future prospects
    Chapter 14. Design of artificial cells
    Chapter 15. Cell-free synthetic biology
    Chapter 16. Artificial photosynthesis
    Chapter 17. Engineering synthetic ecosystems

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