Surface Activity in Drug Action

Edited by

R.C. Srivastava, Birla Institute of Technology and Science, Pilani, India
A.N. Nagappa, Birla Institute of Technology and Science, Pilani, India

Surface activity is present in living systems; for example in body fluid or cell soup and molecules of surface-active nature are crucial to living matter and its organization. Surface Activity in Drug Action proposes "a liquid membrane hypothesis of drug action" for surface-active drugs. Chapters 1-7 contains an account of the hypothesis and chapter 8 contains a general account of the application of surface activity in therapeutics. The methodology and presentation of the information makes Surface Activity in Drug Action valuable reading for students and researchers interested in surface activity.

Audience
Graduate students, scientists and researchers working in biological chemistry

Included in series
Studies in Interface Science

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Hardbound, 340 Pages

Published: March 2005

Imprint: Elsevier

ISBN: 978-0-444-51715-9

Chapter 1. Introduction and scope
1. Introduction
Chapter 2. Surface activity of drugs
2.1. Analgesics
2.2. Antimicorbials
2.3. Drugs acting on autonomic nervous system
2.4. Antihistamines
2.5. Drugs affecting renal and cardiovascular function
2.6. Drugs acting on central nervous system
2.7. Miscellaneous
Chapter 3. Theories of drug action
3.1. Commonly used terms
3.2. Theories of drug action
3.3. Occupancy theory
Chapter 4. The liquid membrane hypothesis of drug action
4.1. The liquid membrane hypothesis
4.2. The liquid membrane hypothesis of drug action
Chapter 5. Liquid membranes as biomimetic system
5.1. Introduction
5.2. Liquid membranes from cholesterol, lecithinand lecithin-cholesterol mixtures
5.3. Mimicking light-induced transport
5.4. Hydrophilic Pathways
5.5. Mimicking electrical excitability of liquid membrane bilayers
Chapter 6. Role of liquid membranes in drug action-experimental studies
6.1. The design of experiments
6.2. Experimental studies
Chapter 7. Assessment of the Hypothesis
7.1. Implications of the hypothesis
7.2. The liquid membrane hypothesis vis-a-vis existing-theories of drug actions
Chapter 8. Application of surface activity in therapeutics
8.1. Drug Absorption
8.2. Solublizing agents
8.3. Dissolution
8.4. Drug stabilization
8.5. Surfactants in drug targeting
8.6. Surfactants as wetting agents
8.7. Synergistic effects
8.8. Prodrugs
8.9. Surfactants and drug delivery
8.10.Miscellaneous

Surface Activity in Drug Action

Contents