Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels

1st Edition, Volume 123 - September 23, 2015
Editors: Paul A. Slesinger, Kevin Wickman
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 0 2 4 5 8 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 2 6 3 1 - 1

This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current k… Read more

Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels

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This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field.

Preface
Chapter One: Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides
- Abstract
- 1 Introduction
- 2 Regulation of K_ACh by G Proteins
- 3 Molecular Constituents of Kir3 Channels and Physiological Roles
- 4 Dependence of K_ACh Channel Activity on PIPs
- 5 Physiological Significance of Distinct Membrane-Delimited Signaling Mechanisms
- 6 Molecular Mechanism of PIP₂ Control of Kir Channel Gating
- 7 Posttranslational Modification Can Control Activity Through Changes in Channel–PIP₂ Interactions
- 8 The Kir3 Channel Site of Gβγ Action
Chapter Two: The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels
- Abstract
- 1 Introduction
- 2 Interaction of Gα and Gβγ With GIRK
- 3 Roles of Gβγ and Gα in GIRK's Evoked and Basal Activity
- 4 Basal Activity of GIRKs
- 5 Multimolecular Signaling Complex and the Mechanism of GIRK Activation
- Acknowledgments
Chapter Three: RGS Redundancy and Implications in GPCR–GIRK Signaling
- Abstract
- 1 RGS Proteins—Background and Significance
- 2 Direct “Membrane-Delimited” GPCR-to-Ion Channel Signaling
- 3 RGS Actions on GPCR–GIRK Channel Gating Kinetics
- 4 RGS Functional Redundancy—Emerging Evidence from Retinal Neurons
- 5 RGS Functional Redundancy in Neuronal GPCR–GIRK Channel Signaling
- 6 RGS Functional Redundancy in Cardiac GPCR-GIRK Channel Signaling
- 7 RGS Actions on G_q-Mediated Changes in GIRK Channel Activity
- 8 Conclusions
Chapter Four: Structural Insights into GIRK Channel Function
- Abstract
- 1 Introduction
- 2 Selectivity and Permeation
- 3 Rectification
- 4 Gating
- 5 Conclusions
- Acknowledgments
Chapter Five: Localization and Targeting of GIRK Channels in Mammalian Central Neurons
- Abstract
- 1 Introduction
- 2 Molecular Organization and Heterogeneity of GIRK Channels
- 3 Neuroanatomical Approaches to the Study of GIRK Channel Distribution
- 4 Regional Distribution of GIRK Channel Subunits in the CNS
- 5 Cellular Distribution of GIRK Channel Subunits
- 6 Subcellular Distribution of GIRK Channel Subunits
- 7 Developmental Aspects of GIRK Channel Distribution
- 8 Conclusions and Future Perspectives
- Acknowledgments
Chapter Six: GIRK Channel Plasticity and Implications for Drug Addiction
- Abstract
- 1 Introduction
- 2 GIRK Channels in the Mesocorticolimbic System
- 3 Drug-Dependent Plasticity of GIRK Channel-Dependent Signaling
- 4 Mechanisms Underlying the Plasticity of GIRK Channel-Dependent Signaling
- 5 Concluding Thoughts and Future Directions
- Acknowledgments
Chapter Seven: GIRK Channels: A Potential Link Between Learning and Addiction
- Abstract
- 1 Introduction
- 2 GIRK Channels
- 3 GIRK Channel Modulation by Drugs of Abuse
- 4 Neuronal Plasticity
- 5 Summary and Future Directions
Chapter Eight: Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction
- Abstract
- 1 Introduction
- 2 GIRK Channels in CNS Disorders
- 3 GIRK Channels in Addiction
- 4 Therapeutic Potential of GIRK Channel Modulators
- 5 Concluding Remarks and Future Directions
- Acknowledgments
Index
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Paul A. Slesinger

Kevin Wickman