Stroke book cover


Pathophysiology, Diagnosis, and Management (Expert Consult - Online and Print)

First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more, equipping you to understand the latest scientific discoveries and make effective use of the newest approaches to diagnosis and treatment. Plus, a new organization and new full-color images make diagnosis easier and more efficient, and full-text online access at allows you to rapidly search this indispensable reference from any computer.


Neurology, Neurosurgery, Cardiology and Physical Medicine & Rehabilitation

Hardbound, 1520 Pages

Published: March 2011

Imprint: Saunders

ISBN: 978-1-4160-5478-8


  • section one


    Michael A. Moskowitz

    Vascular Biology and Atherosclerosis of Cerebral Arteries 03

    Alyson A. Miller, Christopher G. Sobey

    The Cerebral Microvasculature and Responses to Ischemia 16

    Gregory J. del Zoppo, Gerhard F. Hamann

    Mechanisms of Thrombosis and Thrombolysis 29

    Gregory J. del Zoppo, Mary A. Kalafut

    Cerebral Blood Flow and Metabolism in Human Cerebrovascular Disease 44

    Allyson R. Zazulia, Joanne Markham, William J. Powers

    Histopathology of Cerebral Ischemia 68

    ROLAND N. Auer

    Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death 75

    Dimitry Ofengeim, Takahiro Miyawaki, R. Suzanne Zukin

    Apoptosis and Related Mechanisms in Cerebral Ischemia 107

    Turgay Dalkara, Michael A. Moskowitz

    Molecular Pathophysiology of White Matter Anoxic-Ischemic Injury 122

    Bruce R. Ransom, Mark P. Goldberg, Selva Baltan

    Cerebral Ischemia and Inflammation 138

    Costantino Iadecola, Takato Abe, Alexander Kunz, John Hallenbeck

    Intracellular Signaling: Mediators and Protective Responses 154

    Valina L. Dawson, Ted M. Dawson

    Enhancing Brain Reorganization and Recovery of Function after Stroke 162

    Michael Chopp, Zheng Gang Zhang

    Genetics and Vascular Biology of Brain Vascular Malformations 169

    Helen Kim, Ludmila Pawlikowska, William L. Young

    section two

    Epidemiology and Prevention

    Philip A. Wolf

    Distribution of Stroke: Heterogeneity by Age, Race, and Sex 189

    Virginia J. Howard, George Howard

    Epidemiology of Stroke 198

    Philip A. Wolf, William B. Kannel

    Prognosis after Stroke 219

    TATJANA Rundek, Ralph L. Sacco

    16 Primary Prevention of Stroke 242

    Larry B. Goldstein, Ralph L. Sacco

    Vascular Dementia and Vascular Cognitive
    Decline 252

    Sudha Seshadri

    18 Stroke Genetics 268

    James F. Meschia, Daniel Woo

    19 The Global Burden of Stroke 279

    Kathleen Strong, Colin Mathers

    section three

    Clinical Manifestations

    J.P. Mohr

    Classification of Ischemic Stroke 293

    Danilo Toni, Ralph L. Sacco, Michael Brainin, J.P. Mohr


    Clinical Scales to Assess Patients with Stroke 307

    Harold P. Adams, Jr.

    Carotid Artery Disease 334

    J.P. Mohr, Henning Mast

    Anterior Cerebral Artery Disease 362

    John C.M. Brust, Angel Chamorro


    Middle Cerebral Artery Disease 384

    J.P. Mohr, Ronald M. Lazar, Randolph S. Marshall

    Posterior Cerebral Artery Disease 425

    J.P. Mohr, Jeffrey R. Binder

    Vertebrobasilar Disease 446

    J.P. Mohr, Louis R. Caplan

    Microangiopathies (Lacunes) 485

    J.L. Martí-Vilalta, Adrià Arboix, J.P. Mohr

    Cerebral Venous Thrombosis 516

    José M. Ferro, Patrícia Canhão

    Intracerebral Hemorrhage 531

    Carlos S. Kase, Steven M. Greenberg, J.P. Mohr, Louis R. Caplan

    Aneurysmal Subarachnoid Hemorrhage 589

    Eric M. Bershad, José I. Suarez

    Arteriovenous Malformations and Other Vascular Anomalies 616

    Christian Stapf, J.P. Mohr, Andreas Hartmann,
    Henning Mast, Alexander Khaw, Jae H. Choi,
    John Pile-Spellman

    32 Spinal Cord Ischemia 643

    Joshua Z. Willey, Henry J.M. Barnett, J.P. Mohr

    section four

    Specific Medical Diseases and Stroke

    J.P. Mohr

    Arterial Dissections and Fibromuscular
    Dysplasia 661

    Richard M. Zweifler, Gerald Silverboard

    Collagen Vascular and Infectious Diseases 687

    Sachin Agarwal, J.P. Mohr, Mitchell S.V. Elkind

    Moyamoya Disease 703

    Masahiro Yasaka, Junichi Masuda, Jun Ogata, Takenori Yamaguchi

    Migraine and Stroke 720

    Hans C. Diener, Tobias Kurth

    Hypertensive Encephalopathy 734

    Catherine Lamy, Jean-Louis Mas

    Atherosclerotic Disease of the Proximal Aorta 741

    Marco R. Di Tullio, Shunichi Homma

    CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 758

    Hugues Chabriat, Anne Joutel, Elisabeth Tournier-Lasserve, Marie-Germaine Bousser

    Reversible Cerebral Vasoconstriction
    Syndromes 765

    Aneesh B. Singhal, Anne Ducros

    Coagulation Abnormalities in Stroke 772

    Bruce M. Coull, Kendra Drake

    Stroke and Substance Abuse 790

    John C.M. Brust

    Cardiac Diseases 814

    David M. Greer, Shunichi Homma, Karen L. Furie

    section five

    Diagnostic Studies

    Rüdiger von Kummer

    Ultrasonography 831

    Stephen Meairs, Michael Hennerici, J.P. Mohr

    Computed Tomography-Based Evaluation of Cerebrovascular Disease 870

    Imanuel Dzialowski, Volker Puetz, Rüdiger von Kummer

    Magnetic Resonance Imaging of Cerebrovascular Diseases 882

    Steven Warach, Alison E. Baird, Krishna A. Dani, Max Wintermark, Chelsea S. Kidwell

    47 Cerebral Angiography 910

    Ronald J. Sattenberg, Jeffrey L. Saver, Y. Pierre Gobin, David S. Liebeskind

    section six


    Part A: Medical Therapy

    James C. Grotta

    Prehospital and Emergency Department Care of the Patient with Acute Stroke 929

    Opeolu Adeoye, Arthur Pancioli

    Intravenous Thrombolysis 945

    Wendy Brown, Lama Al-Khoury, Gilda Tafreshi, Patrick D. Lyden

    Antithrombotic Therapy for Treatment of Acute Ischemic Stroke 971

    Harold P. Adams, Jr., Patricia H. Davis

    General Stroke Management and Stroke Units 992

    Markku Kaste, Risto O. Roine

    Critical Care of the Patient with Acute Stroke 1008

    Jennifer Diedler, Marek Sykora, Werner Hacke

    Pharmacologic Modification of Acute Cerebral Ischemia 1049

    Nicole R. Gonzales, James C. Grotta

    Treatment of "Other" Stroke Etiologies 1084

    Scott E. Kasner, Brett L. Cucchiara

    Medical Therapy of Intracerebral and
    Intraventricular Hemorrhage 1106

    Lewis B. Morgenstern, Darin B. Zahuranec

    Rehabilitation and Recovery of the Patient with Stroke 1116

    Bruce H. Dobkin

    Enhancing Stroke Recovery with Cellular
    Therapies 1134

    Sean I. Savitz

    Antiplatelet Therapy for Secondary Prevention of Stroke 1147

    Mar Castellanos, Babette B. Weksler, Oscar R. Benavente

    Secondary Prevention of Cardioembolic
    Stroke 1173

    Maria I. Aguilar, Oscar R. Benavente

    Conduct of Stroke-Related Clinical Trials 1192

    Barbara C. Tilley, Yuko Y. Palesch

    Part B: Interventional Therapy

    Rüdiger von Kummer

    Interventional Neuroradiologic Therapy
    of Atherosclerotic Disease and Vascular Malformations 1204

    J Mocco, Stanley H. Kim, Bernard R. Bendok,
    Alan S. Boulos, L. Nelson Hopkins, Elad I. Levy

    Intraarterial Thrombolysis in Acute Ischemic
    Stroke 1227

    Anthony J. Furlan, Jitendra Sharma, Randall Higashida

    Endovascular Treatment of Cerebral
    Aneurysms 1241

    Ajay K. Wakhloo, Matthew J. Gounis, Michael J. De Leo III

    Interventional Therapy of Brain and Spinal Arteriovenous Malformations 1255

    Timo Krings, Sasikhan Geibprasert, Karel ter Brugge

    65 Dural Arteriovenous Malformations 1280

    J. Paul Elliott, Daniel Huddle, Issam A. Awad

    Part C: Surgical Therapy

    Marc R. Mayberg

    Genetics of Aneurysms and Arteriovenous Malformations 1292

    Ynte M. Ruigrok, CATHARINA  J.M. Klijn

    67 Anterior Circulation Aneurysms 1301

    Brian V. Nahed, Christopher S. Ogilvy

    Surgical Management of Posterior Circulation Aneurysms 1322

    Mark J. Dannenbaum, Rose Du, Arthur L. Day

    69 Surgery for Intracerebral Hemorrhage 1336

    Alexander David Mendelow, BARBARA A. GREGSON

    70 Intraventricular Hemorrhage 1349

    J. Max Findlay

    Surgical Decision Making, Techniques, and Periprocedural Care of Cerebral Arteriovenous Malformations 1358

    Robert M. Starke, Ricardo J. Komotar, E. Sander Connolly

    72 Spinal Arteriovenous Malformations 1366

    Shervin R. Dashti, Louis J. Kim, Udaya K. Kakarla, Min S. Park, Michael F. Stiefel, Robert F. Spetzler

    Radiosurgery for Arteriovenous
    Malformations 1374

    William A. Friedman, Frank J. Bova

    Cerebral Cavernous Malformations and Venous Anomalies: Diagnosis, Natural History, and Clinical Management 1388

    Christopher S. Eddleman, H. Hunt Batjer, Issam A. Awad

    Indications for Carotid Endarterectomy in Patients with Symptomatic Stenosis 1398

    Jonathan L. Brisman, Marc R. Mayberg

    Surgical Management of Asymptomatic Carotid Stenosis 1403

    Mohamed Samy Elhammady, Roberto C. Heros, Jacques J. Morcos

    Extracranial to Intracranial Bypass for Cerebral Ischemia 1417

    David W. Newell, Marcelo D. Vilela

    78 Cerebral Infarction: Surgical Treatment 1426

    Eric Jüttler, Werner Hacke

    79 Cerebellar Infarction and Hemorrhage 1440

    Tetsuyoshi Horiuchi, Kazuhiro Hongo, Shigeaki Kobayashi

    Index 1447


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