Strategies and Tactics in Organic Synthesis
- Michael Harmata, University of Missouri, USA
A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.View full description
Organic chemists; academic libraries, chemical and pharmaceutical companies
- Published: July 2005
- Imprint: ACADEMIC PRESS
- ISBN: 978-0-12-450288-8
"This book is a chronicle of synthetic problems and strategies written by leading organic chemists, who give their own personal accounts of the practice of organic synthesis. It is part lab. notes and memoir and should be an interesting read for both organic chemistry students and practitioners alike."
J. AM. CHEM. SOC, Vol. 128, no. 10, 2006
Table of ContentsChapter 1. The Total Synthesis OfLuzopeptins (M.A. Ciufolini).Chapter 2. Synthesis of GeldanamycinUsing Glycolate Aldol Reactions (M.B. Andrus et al.).Chapter 3. From Methylene Bridged GlycolurilDimers To Cucurbit[N]Uril Analogs With Some Detours Along The Way (L. Isaacs, J. Lagona). Chapter 4. Application Of Silicon-AssistedIntramolecular Cross-Coupling InTotal Synthesis Of (+)-Brasilenyne (S.E. Denmark, Shyh-Ming Yang). Chapter 5. Samarium(II) Promoted Ketyl OlefinCyclizations Applied To The TotalSyntheses Of (-)-Steganone And(+)-Isoschizandrin (G.A. Molander, K.M. George). Chapter 6. The Synthesis Of Polycavernoside A.An Example Of Conformationally GuidedMacrolactonization (P.R. Blakemore, J.D. White). Chapter 7. First Total Synthesis Of Several NaturalProducts Based On Alkyne-Co2(Co)6 Complexes (Chisato Mukai). Chapter 8. Total Synthesis Of Myriaporones 1, 3, and 4 (R.E. Taylor et al.).Chapter 9. Adventures In Natural Product Synthesis:From Deep Sea Sponge To Pilot Plant. The Large Scale Total Synthesis Of The MarineNatural Product (+)-Discodermolide (S.J. Mickel). Chapter 10. Synthesis Of Aprepitant (T.D. Nelson). Chapter 11. Total Synthesis And Mechanism Of ActionStudies On The Antitumor Alkaloid,(-)-Agelastatin A(K.J. Hale, M.M. Domostoj). Chapter 12. Design And Synthesis of Cooperative"Pinwheel" Fluorescent Sensors (J. Raker et al.).Chapter 13. Functionalization Of Pyridines AndThiazoles Via The Halogen-Dance Reaction,Application To The Total Synthesis OfCaerulomycin C And WS75624 B (T. Sammakia et al.).Chapter 14. Diastereoselective Intramolecular4+3 Cycloaddition And An EnantioselectiveTotal Synthesis Of (+)-Dactylol (P. Rashatasakhon, M. Harmata).