Stem Cells in Development and Disease book cover

Stem Cells in Development and Disease

This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging

Researchers in cell, developmental, and molecular biology; genetics

Hardbound, 472 Pages

Published: January 2014

Imprint: Academic Press

ISBN: 978-0-12-416022-4


  • 1. Mechanisms of Pluripotency In Vivo and In Vitro
    Eszter Posfai, Oliver H. Tam, and Janet Rossant
    2. Hematopoietic Stem Cell Development: An Epigenetic Journey
    Sean M. Cullen, Allison Mayle, Lara Rossi, and Margaret A. Goodell
    3. Intestinal Stem Cells and their Defining Niche
    David Wei-Min Tan and Nick Barker
    4. Epithelial Stem Cells in Adult Skin
    Ana Mafalda Baptista Tadeu and Valerie Horsley
    5. The Mammary Stem Cell Hierarchy
    Naiyang Fu, Geoffrey J. Lindeman, and Jane E. Visvader
    6. Satellite Cells: The Architects of Skeletal Muscle
    Natasha C. Chang and Michael A. Rudnicki
    7. Neural Stem Cells of the Hippocampus: Development, Physiology Regulation and Dysfunction in Disease
    Chiara Rolando and Verdon Taylor
    8. Lung Stem and Progenitor Cells in Tissue Homeostasis and Disease
    Kristen T. Leeman, Christine M. Fillmore, and Carla F. Kim
    9. Spermatogonial Stem Cell Functions in Physiological and Pathological Conditions
    Qi-En Yang and Jon M. Oatley
    10. The Origin, Biology, and Therapeutic Potential of Facultative Adult Hepatic Progenitor Cells
    Soona Shin and Klaus H. Kaestner
    11. Nephron Progenitor Cells: Shifting the Balance of Self-Renewal and Differentiation
    Raphael Kopan, Shuang Chen, and Melissa Little
    12. Adult Stem Cell Niches: Cellular and Molecular Components
    Amélie Rezza, Rachel Sennett, and Michael Rendl
    13. Cancer Stem Cells, Pluripotency, and Cellular Heterogeneity: A WNTer Perspective
    Yaser Atlasi, Leendert Looijenga, and Riccardo Fodde
    14. Cellular Mechanisms of Somatic Stem Cell Aging
    Yunjoon Jung and Andrew S. Brack


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