Spinal Cord Trauma: Regeneration, Neural Repair and Functional Recovery
- L. McKerracher
- G. Doucet
- S. Rossignol, Centre for Research in Neurological Sciences, Department of Pathology and Cellular Biology, Faculty of Medicine, Université de Montréal, 2900 Édouard-Montpetit, Montreal PQ H3T 1JB, Canada
View full description
This book covers, in a broad perspective, research on spinal cord injury, beginning with human spinal cord injury to experimental studies in animals, to molecular mechanisms of injury and regeneration.
Every year 12,000 will suffer spinal cord injury leading to permanent disability. In the last five years enormous progress has been made in the understanding of spinal cord injury, and in ways to elicit repair in animal models of spinal cord injury. The scope includes animal models of spinal cord injury, strategies for neuroprotection and regeneration, and possible roles of axon guidance molecules in injury and regeneration. Topical reviews are presented as well as new data on timely issues in spinal cord injury research.
- Published: October 2002
- Imprint: ELSEVIER
- ISBN: 978-0-444-50817-1
Table of ContentsList of contributors. Foreword by Christopher Reeve. Preface. Section I. Spinal Cord Injuries in Patients. 1. Advances in imaging of spinal cord injury: implications for treatment and patient evaluation(R.M. Quencer). 2. A review of the adaptability and recovery of locomotion after spinal cord injury (H. Barbeau et al.). 3. Electrical stimulation for therapy and mobility after spinal cord injury (R.B. Stein et al.). Section 2. Spinal Cord Injuries in Animal Models. 4. Cell death in models of spinal cord injury (M.S. Beattie et al.). 5. Gray matter repair in the cervical spinal cord (P.J. Reier et al.). 6. Spinal cord neural organization controlling the urinary bladder and striated sphincter (S.J. Shefchyk). 7. Central mechanisms for autonomic dysreflexia after spinal cord injury(L.C. Weaver et al.). 8. The spinal locomotor CPG - a target after spinal cord injury (S. Grillner). 9. Activation and coordination of spinal motoneuron pools after spinal cord injury(A. Prochazka et al.). 10. Propriospinal neurons involved in the control of locomotion: potential targets for repair strategies? (L.M. Jordan, B.J. Schmidt). 11. Use of robotics in assessing the adaptive capacity of the rat lumbar spinal cord (R.D. de Leon et al.). 12. The cat model of spinal injury (S. Rossignol et al.). Section 3. Neuroprotection and transplantation. 13. Neurotrauma/neurodegeneration and mitochondrial dysfunction(M. Frantseva et al.). 14. Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker Riluzole (G. Schwartz, M.G. Fehlings). 15. Strategies for regeneration and repair in spinal cord traumatic injury (M. Giménez y Ribotta et al.). 16. Locomotor recovery in chronic spinal rat: long-term pharmacological treatment or transplantation of embryonic neurons (D. Orsal et al.). 17. Spinal Cord Contusion Models(W. Young). 18. Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury(B.S. Bregman et al.). 19. Bridging the transected or contused adult rat spinal cord with Schwann cell and olfactory ensheathing glia transplants (M.B. Bunge). 20. Potent possibilities: endogenous stem cells in the adult spinal cord(A.C. Lipson, P.J. Horner). 21. Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelination (J.W. McDonald, M.J. Howard). Section 4. Molecular targets to promote axon regeneration in the CNS. 22. Chondroitin sulfate proteoglycans in the CNS injury response (D.A. Morgenstern et al.). 23. The extracellular matrix in axon regeneration (B. Grimpe, J. Silver). 24. Increasing plasticity and functional recovery of the lesioned spinal cord (M.E. Schwab). 25. Nogo and the Nogo-66 receptor(A.E. Fournier et al.). 26. Inactivation of intracellular Rho to stimulate axon growth and regeneration(B. Ellezam et al.). 27. A role for cAMP in regeneration during development and after injury (J. Qiu et al.). 28. Inosine stimulates axon growth in vitro and in the adult CNS(L.I. Benowitz et al.). 29. T-cell based therapeutic vaccination for spinal cord injury (M. Schwartz, E. Hauben). 30. Recruiting the immune response to promote long distance axon regeneration after spinal cord injury (S. David). 31. Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury (A. Blesch, M.H. Tuszynski). 32. Where the rubber meets the road: netrin expression and function in developing and adult nervous systems (C. Manitt, T.E. Kennedy). 33. Reinnervation of the pretectum in adult rats by regenerated retinal ganglion cell axons: anatomical and functional studies (M. Vidal-Sanz et al.). 34. Seeking axon guidance molecules in the adult rat CNS (G. Doucet, A. Petit). Subject Index.