Spinal Cord Injury book cover

Spinal Cord Injury

Handbook of Clinical Neurology Series

Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists.


Neuroscience and Clinical Neurology research specialists and practicing neurologists.

Hardbound, 656 Pages

Published: November 2012

Imprint: Elsevier

ISBN: 978-0-444-52137-8


  • "Providing the latest information on all aspects of spinal cord injury, this volume supplants a 1992 work published in the Handbook of Clinical Neurology series titled Spinal Cord Trauma. Bridging the gap between bench and bedside, coverage encompasses diagnosis and prognosis; medical, surgical, and rehabilitative management of acute spinal cord injury; therapies for chronic spinal cord injury; and preclinical research."--Reference & Research Book News, October 2013


  • Foreword


    List of contributors

    Section 1 Developmental and anatomical perspectives

    1. Development and maturation of the spinal cord: implications of molecular and genetic defects

    2. Anatomy and biomechanics of the spinal column and cord

    Section 2 Diagnosis and prognosis

    3. Clinical diagnosis and prognosis following spinal cord injury

    4. Clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury

    5. Concepts of aging with paralysis: implications for recovery and treatment

    6. Advanced MRI strategies for assessing spinal cord injury

    Section 3 Acute spinal cord injury: medical, surgical, and rehabilitative management

    7. Advances in the management of spinal cord and spinal column injuries

    8. Spinal cord injuries in children and adolescents

    9. The changing landscape of spinal cord injury

    10. Surgical treatments to restore function control in spinal cord injury

    11. Advances in the rehabilitation management of acute spinal cord injury

    12. Spasticity

    13. Disordered cardiovascular control after spinal cord injury

    14. New concepts in the prevention of pressure sores

    15. Functional electrical stimulation for bladder, bowel, and sexual function

    16. Evidence-based therapy for recovery of function after spinal cord injury

    17. Functional electrical stimulation: restoration of respiratory function

    18. Spinal cord stimulation: therapeutic benefits and movement generation after spinal cord injury

    19. Promoting optimal functioning in spinal cord injury: the role of rehabilitation psychology

    Section 4 Chronic spinal cord injury - the changing perspective of neurorestorative rehabilitation, activity-based and surgical restoration therapies

    20. The changing field of rehabilitation: optimizing spontaneous regeneration and functional recovery

    21. The longitudinal spinal cord injury: lessons from intraspinal plexus, cauda equina and medullary conus lesions

    22. Post-traumatic syringomyelia: CSF hydrodynamic changes following spinal cord injury are the driving force in the development of PTSM

    23. Post-traumatic deformity: prevention and management

    Section 5 Preclinical research - bridging the gap between bench and bedside

    24. Spinal cord injury clinical trials: translational process, review of past and proposed acute trials with reference to recommended trial guidelines

    25. Translating preclinical approaches into human application

    26. Translational spinal cord injury research: preclinical guidelines and challenges

    27. Brain-machine interfaces and transcranial stimulation: future implications for directing functional movement and improving function after spinal injury in humans

    28. Approaches to repairing the damaged spinal cord: overview

    29. Limiting spinal cord injury by pharmacological intervention

    30. Harmful and beneficial effects of inflammation after spinal cord injury: potential therapeutic implications

    31. Defeating inhibition of regeneration by scar and myelin components

    32. Realizing the maximum potential of Schwann cells to promote recovery from spinal cord injury

    33. Repair of central nervous system lesions by transplantation of olfactory ensheathing cells

    34. Cell transplantation: stem cells and precursor cells

    35. Gene therapy, neurotrophic factors and spinal cord regeneration

    36. Scaffolds to promote spinal cord regeneration

    37. Molecular target discovery for neural repair in the functional genomics era

    38. Combination therapies



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