Sleep Disorders Part I book cover

Sleep Disorders Part I

Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)

Since the late 90’s, a renewed interest in the neurobiology of sleep has provided new advancements in the understanding of basic sleep science and the clinical aspects of sleep disorders, with particular interest given to the role of genetics.

From laboratory techniques and therapies, groundbreaking research in sleep-wakefulness, new models of rapid eye movement (REM) sleep mechanisms, to bright light therapy for circadian rhythm sleep disorders, this handbook will provide clinicians and researchers with a state-of-the-art reference that summarizes the clinical features and management of the many neurological manifestations of sleep disorders.

Practitioners will find invaluable research, information, and laboratory techniques on such topics as sleep-wake-dependent genes, the role of sleep duration in mortality and morbidity, and advancements in the understanding of the neurobiology of sleep disorders, including narcolepsy-cataplexy, restless legs syndrome, REM behavior disorders, fatal familiar insomnia, sleep apnea and heart failure, and nocturnal paroxysmal dystonia, amongst others. In addition, significant advancements in therapies and drug protocols are presented.

Neuroscience research workers

Hardbound, 720 Pages

Published: December 2010

Imprint: Elsevier

ISBN: 978-0-444-52006-7


  • SECTION 1: History of sleep medicine

    History of sleep medicine.

    SECTION 2: Basic science and methods

    Normal sleep- recording and scoring techniques. Assessment of daytime sleepiness. Actigraphic monitoring of sleep and circadian rhythms. Video Recordings and Video Polysomnography. Functional neuroimaging in sleep, sleep deprivation and sleep disorders.

    SECTION 3: Basic mechanisms of sleep

    The Phylogeny of Sleep. Ontogeny of EEG-sleep from neonatal through infancy periods. Neurobiology of waking and sleeping. Neurobiology of REM sleep. Neurochemistry of sleep - an overview of animal experimental work. Molecular neurobiology of sleep. Manifestations and functional implications of sleep homeostasis. Thermoregulation in wakefulness and sleep in humans. Cytokines in immune function and sleep regulation. Endocrine and metabolic changes during sleep. Sleep, memory and molecular neurobiology.

    SECTION 4: Clinical aspects of sleep disorders

    Epidemiology of sleep disorders. Cardiovascular and cerebrovascular physiology in sleep. Cardiovascular diseases and sleep apnea. Alterations in gastrointestinal functioning during sleep. Sleep and genitourinary systems: physiology and disorders. Sleep enuresis. Respiratory physiology in sleep and wakefulness. Obstructive sleep apnea: diagnosis, risk factors and pathophysiology. Upper airway resistance syndrome. Central sleep apnea. Positive pressure treatment of obstructive sleep apnea syndrome. Medical and surgical treatment of obstructive sleep apnea syndrome, including dental appliances. Non-invasive positive ventilation in the treatment of sleep related breathing disorders. Sleep and pulmonary diseases. Sleep-associated respiratory disorders and their psycho-behavioral consequences in children. Sudden death in infants during sleep. Neurobiology and the neurological basis of dreaming. Abnormal dreams and nightmare disorders. Sleep and psychiatric diseases. Sleep-related eating disorder. Alcohol, toxins and medications as a cause of sleep dysfunction. Sleep, pain, fibromyalgia and chronic fatigue syndrome. Women and sleep. Normal and abnormal sleep in the elderly.


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