Sleep Disorders Part I

Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)

Edited by

  • P. Montagna, Department of Neurological Sciences, University of Bologna, Italy
  • Sudhansu Chokroverty, MD, FRCP, FACP, Professor and Co-Chair of Neurology, Program Director, Clinical Neurophysiology and Sleep Medicine, New Jersey Neuroscience Institute at JFK Medical Center and Seton Hall University, Edison, New Jersey; Clinical Professor of Neurology, Robert Wood Johnson Medical School, New Brunswick, New Jersey

Sleep Disorders Part 1 offers a glimpse of developments that focus on diagnostic techniques in the field of neurobiology of sleep. This part discusses the models of the rapid eye movement (REM) sleep mechanism; issues regarding sleep states, stages, and memory consolidation; and advances in the understanding of the sleep-wake genes, gene products, the circadian clock, and the role of sleep duration. This book explains noninvasive neuroimaging studies, particularly positron emission tomographic and single photon emission computed tomographic scans. It further discusses advances in clinical science, including concepts about neurobiology of sleep, narcolepsy-cataplexy, therapy, and laboratory techniques. The significant advances in therapy have led to the addition of new drugs for the treatment of different sleeping disorders, as described in this book. Sleep is essential to humans. Awareness of its true importance leads to the development and acceptance of sleep medicines in the market.
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Book information

  • Published: December 2010
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-52006-7

Table of Contents




List of contributors

Section 1 History of sleep medicine

    1. History of sleep medicine

Section 2 Basic science and methods

    2. Normal sleep-recording and scoring techniques

    3. Assessment of daytime sleepiness

    4. Actigraphic monitoring of sleep and circadian rhythms

    5. Video recordings and video polysomnography

    6. Functional neuroimaging in sleep, sleep deprivation, and sleep disorders

Section 3 Basic mechanisms of sleep

    7. The phylogeny of sleep

    8. Ontogeny of EEG sleep from neonatal through infancy periods

    9. Neurobiology of waking and sleeping

    10. Neurobiology of REM sleep

    11. Neurochemistry of sleep: an overview of animal experimental work

    12. Molecular neurobiology of sleep

    13. Manifestations and functional implications of sleep homeostasis

    14. Thermoregulation in wakefulness and sleep in humans

    15. Cytokines in immune function and sleep regulation

    16. Endocrine and metabolic changes during sleep

    17. Sleep, memory, and molecular neurobiology

Section 4 Clinical aspects of sleep disorders

    18. Epidemiology of sleep disorders

    19. Cardiovascular and cerebrovascular physiology in sleep

    20. Cardiovascular diseases and sleep apnea

    21. Alterations in gastrointestinal functioning during sleep

    22. Sleep and genitourinary systems: physiology and disorders

    23. Sleep enuresis

    24. Respiratory physiology in sleep and wakefulness

    25. Obstructive sleep apnea: diagnosis, risk factors, and pathophysiology

    26. Upper-airway resistance syndrome

    27. Central sleep apnea

    28. Positive-pressure treatment of obstructive sleep apnea syndrome

    29. Medical and surgical treatment of obstructive sleep apnea syndrome, including dental appliances

    30. Noninvasive positive ventilation in the treatment of sleep-related breathing disorders

    31. Sleep and pulmonary diseases

    32. Sleep-associated respiratory disorders and their psychobehavioral consequences in children

    33. Sudden death in infants during sleep

    34. Neurobiology and the neurological basis of dreaming

    35. Abnormal dreams and nightmare disorders

    36. Sleep and psychiatric diseases

    37. Sleep-related eating disorder

    38. Alcohol, toxins, and medications as a cause of sleep dysfunction

    39. Sleep, pain, fibromyalgia, and chronic fatigue syndrome

    40. Women and sleep

    41. Normal and abnormal sleep in the elderly