Signal Transduction


  • Ijsbrand Kramer, University of Bordeaux, Talence, France
  • Bastien Gomperts, University College, London, UK
  • Ijsbrand Kramer, University of Bordeaux, Talence, France
  • Peter Tatham, University College, London, UK

Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields.
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Established researchers as well as advanced undergraduate and graduate researchers, and scientists working in cell biology, pharmacology, immunology, and related fields.


Book information

  • Published: September 2015
  • ISBN: 978-0-12-369441-6

Table of Contents

Chapter 1 Prologue: Signal Transduction, origins and ancestorsChapter 2 First messengersChapter 3 ReceptorsChapter 4 GTP-binding proteins and signal transductionChapter 5 Effector enzymes coupled to GTP binding proteins: adenylyl cyclase and phospholipase CChapter 6 The regulation of visual transduction and olfactionChapter 7 Intracellular calciumChapter 8 Calcium effectorsChapter 9 Phosphorylation and dephosphorylation: protein kinases A and CChapter 10 Nuclear receptorsChapter 11 Growth Factors: setting the frameworkChapter 12 Signalling pathways operated by receptor protein tyrosine kinasesChapter 13 Signal transduction to and from adhesion moleculesChapter 14 Adhesion molecules in the regulation of cell differentiation: Mainly about WntChapter 15 Activation of the innate immune system: the Toll-like receptor 4 and Signalling through UbiquitylationChapter 16 Traffic of white blood cellsChapter 17 Tyrosine protein kinases and adaptive immunity : TCR, BCR, soluble tyrosine kinases and NFATChapter 18 Phosphoinositide 3 kinases, protein kinase B and signalling through the insulin receptorChapter 19 Protein Kinase C revisitedChapter 20 Signalling through receptor serine/threonine kinasesChapter 21 Protein dephosphorylation and protein phosphorylationChapter 22 NotchChapter 23 Targeting transduction pathways for research and medical interventionChapter 24 Protein domains and signal transduction