Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance

Edited by

  • Giuseppe Di Giovanni, Dipartimento di Medicina Sperimentale, Sezione di Fisiologia Umana, ''G. Pagano'', Universita` di Palermo, Italy
  • Vincenzo Di Matteo, Istituto di Ricerche Farmacologiche Mario Negri, Italy
  • Ennio Esposito, Istituto di Ricerche Farmacologiche Mario Negri, Italy

This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson’s disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners and students. The book provides a valuable contribution to the debate on new pharmacological approaches for several psychopathological states, with contributions from expert neuroscientists and pharmacologists who comprehensively survey the most significant currently active areas of dopamine/serotonin interactions.
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Clinical Psychiatrists, Primary Care Physicians, and specialists in the behavioral health community. Also Graduate students and researchers involved with serotonergic and dopaminergic systems. Possibly Pharmaceutical companies who market dopaminergic and serotonergic drugs


Book information

  • Published: September 2008
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-53235-0

Table of Contents

1. SEROTONIN-DOPAMINE INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM1. Serotonin-Dopamine Interaction: an overviewE. Esposito, V. Di Matteo and G. Di Giovanni (Santa Maria Imbaro, Chieti and Palermo, Italy)2. Serotonin control of central dopaminergic function: focus on in vivo microdialysis studiesV. Di Matteo, G. Di Giovanni, M. Pierucci and E. Esposito (Santa Maria Imbaro, Chieti and Palermo, Italy)3. Serotonin-Dopamine Interaction: electrophysiological evidenceG. Di Giovanni, V. Di Matteo, M. Pierucci and E. Esposito (Palermo and Santa Maria Imbaro, Chieti, Italy4. Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disordersU.M. D’Souza and I.W. Craig (London, UK)2. SEROTONIN-DOPAMINE INTERACTIONS IN SCHIZOPHRENIA5. Distribution of 5-HT and DA receptors in primate prefrontal cortex: implications for pathophysiology and treatmentJ. de Almeida, J.M. Palacios and G. Mengod (Barcelona, Spain)6. Alterations of dopamine and serotonin transmission in schizophreniaG. Remington (Toronto, ON, Canada)7. Serotonin and dopamine interactions in psychosis preventionN.M. Richtand and R.K. McNamara (Cincinnati, OH, USA)8. Role of serotonin and dopamine receptor binding in antipsychotic efficacyN.M. Richtand, J.A. Welge, A.D. Logue, P.E. Keck, Jr., S.M. Strakowski and R.K. McNamara (Cincinnati, OH, USA)9. In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systemsH.Y. Meltzer and M. Huang (Nashville, TN, USA)10. Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin-dopamine hypothesisT. Kuroki, N. Nagao and T. Nakahara (Kanzaki, Japan)11. Serotonin-dopamine interactions: implications for the design of novel therapeutic agents for psychiatric disordersM.D. Wood and P.W. Wren (Harlow, UK)3. SEROTONIN-DOPAMINE INTERACTIONS IN DEPRESSION12. The dorsal raphe nucleus and serotonin —implications for neuroplasticity linked to major depression and Alzheimer’s diseaseK.A. Michelsen, J. Prickaerts and H.W.M. Steinbusch (Maastricht, The Netherlands)13. Dynamics of the dopaminergic system as a key component to the understanding of depressionG. Yadid and A. Friedman (Ramat-Gan, Israel)14. Physiological and therapeutic relevance of constitutive activity of 5-HT2A and 5-HT2C receptors for the treatment of depressionK.A. Berg, J.A. Harvey, U. Spampinato and W.P. Clarke (San Antonio, TX, Philadelphia, PA, USA and Bordeaux, France)15. The role of dopamine and serotonin in suicidal behaviour and aggressionE. Ryding, M. Lindström and L.TrĂ€skman-Bendz (Stockholm, Sweden)4. SEROTONIN-DOPAMINE INTERACTIONS IN DRUG ADDICTION16. Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse M.J. Bubar and K.A. Cunningham (Galveston, TX, USA)17. Pharmacological inhibition of dopamine- and serotonin activity blocks spontaneous and cocaine-activated behaviourR.J. Carey, J.P. Huston and C.P. MĂŒller (Dusseldorf, Germany and London, UK)18. Serotonin receptors as potential targets for modulation of nicotine use and dependenceP.J. Fletcher, A. Dzung LĂȘ and G.A. Higgins (Toronto, ON, Canada)19. Dopamine/Serotonin releasers as medications for stimulant addictionsR.B. Rothman, B.E. Blough and M.H. Baumann (Baltimore, MD and Triangle Park, NC, USA)20. PTEN-5-HT2C coupling: A new target for treating drug addictionJ.-C. Maillet, Y. Zhang, X. Li, X. Zhang (Ottawa, ON, Canada)5. SEROTONIN-DOPAMINE INTERACTIONS IN MOTOR DISORDERS21. Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson’s disease and other motor disorders V. Di Matteo, M. Pierucci, E. Esposito, G. Crescimanno, A. Benigno and G. Di Giovanni (Santa Maria Imbaro, Chieti, and Palermo, Italy)22. Serotonin-Dopamine interaction in the induction and maintenance of LDOPA-induced dyskinesiasM. Carta, T. Carlsson, A. Muňoz, D. Kirik and A. Björklund (Lund, Sweden)23. Parkinson’s disease – opportunities for novel therapeutics to reduce the problems of levodopa therapyS.H. Fox, R. Chuang and J.M. Brotchie (Toronto, ON, Canada)24. Neurobiological basis of serotonin-dopamine antagonists in the treatment of Gilles de la Tourette syndrome|T.D.L. Steeves and S.H.Fox (Toronto, ON, Canada)6. SEROTONIN-DOPAMINE INTERACTIONS IN ATTENTIONAL PROCESSES, LEARNING AND MEMORY25. Serotonergic and dopaminergic modulation of attentional processesV. Boulougouris and EL. Tsaltas (Cambridge, UK and Athens, Greece)26. Dopamine-serotonin interactions in attention-deficit/hyperactivity disorder (ADHD)R.D. Oades (Essen, Germany)27. Serotonin/dopamine interaction in learningM.E. Olvera-CortĂ©s, P. Anguiano-RodrĂ­guez, M.Á.LĂłpez-VĂĄzquez, J.M. C. Alfaro (Morelia, Mich., Mexico)28. Serotonin-dopamine interaction in memory formationI. GonzĂĄlez-Burgos and A. Feria-Velasco (Guadalajara, Jal. Mexico)29. The roles of dopamine and serotonin, and of their receptors, in regulating sleep and wakingJ.M. Monti and H. Jantos (Montevideo, Uruguay)