Rosenberg

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Fifth Edition

Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease provides a comprehensive introduction and reference to the molecular and genetic foundations of the majority of neurologic and psychiatric disease. This is an essential reference for the general medical practitioner, a core reference for clinical neurologists, psychiatrists and associated clinical professionals and a general tutorial reference for the neuroscience and clinical neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. This new edition represents a major revision to insure consistent presentation and coverage within each chapter authored by an international line-up of leading research scientists and clinical practitioners.

Previous editions have established this book as the leading tutorial reference on neurogenetics. With this new edition the three key markets, research scientists, clinicians and genetic counselors will all continue to benefit from the content. The research community will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations. And genetic counselors will find this a comprehensive tutorial reference on the latest advances in the science, with links to genetic testing for specific diseases.

Audience

Clinical neurologists, psychiatrists, psychologists, neuroscience researchers, clinical neurology researchers, general medical practitioners, and genetic and molecular biologists with an interest in neurogenetics

Hardbound, 992 Pages

Published: November 2014

Imprint: Academic Press

ISBN: 978-0-12-410529-4

Contents

  • SECTION I. GENERAL CONCEPTS OF DISEASE AND INVESTIGATIONAL TOOLS

    Mendelian, Nonmendelian, Multigenic Inheritance, and Complex Traits

    Repeat Expansion Disorders: General Concepts and Mechanisms of Disease

    Genetically Engineered Models Relevant to Human Neuropsychiatric Disease

    Gene Mapping to Gene Targeting: Application of Mouse Genetics to Human Disease

    Human Genomics and Disease

    Gene Therapy for Central Nervous System Disorders

    Stem cell therapy

    Genotype-Phenotype Correlations

    Neuroimaging

    Analytical biochemistry and metabolomics

    Causation, association and other statistical tools

    DNA sequencing and other methods of genomic analysis

    Registries, sample repositories, ICD-9 and DSM-S

    Ethics in Neurology, Psychiatry, and the Neurosciences

    Genetic counseling in neurology and psychiatry

    SECTION II. NEUROLOGIC DISEASES

    Down Syndrome

    Triplet Repeat Diseases: Overview

    Prion Diseases

    Mitochondrial Disorders:

    The Mitochondrial Genome

    Mitochondrial Disorders Due to Mutations in the Mitochondrial Genome

    Mitochondrial Disorders Due to Mutations in the Nuclear Genome

    Mitochondria in Neurodegenerative Disorders

    Peroxisomal Disorders:

    Lysosomal Disorders:

    Gaucher Disease

    The Niemann-Pick Diseases / The Gm2-Gangliosidoses

    Metachromatic Leukodystrophy and Multiple Sulfatase Deficiency: Sulfatide Lipidosis

    Krabbe Disease: Globoid Cell Leukodystrophy

    The Mucopolysaccharidoses and the Mucolipidoses

    Disorders of Glycoprotein Degradation: Sialidosis, Fucosidosis, Alpha-Mannosidosis, Beta-

    Beta-Galactosidase Deficiency: GMl Gangliosidosis, Morquio B Disease, and Galactosialidosis

    Farber Disease: Acid Ceramidase Deficiency, Farber Lipogranulomatosis

    Wolman Disease

    Lysosomal Membrane Disorders: LAMP-2 Deficiency

    Fabry Disease: Alpha Galactosidase A Deficiency

    Schindler Disease: Deficient Alpha-N-Acetylgalacosaminidase Activity

    Degenerative Disorders:

    Alzheimer's Disease

    Parkinson's Disease

    Frontotemporal Dementias

    Other Movement Disorders

    The Inherited Ataxias

    Friedreich Ataxia

    Ataxia-teleangiectasia

    Hereditary Spastic Paraplegia

    Vanishing White Matter Disease

    Neuro-Oncology:

    Genes and neurological cancer

    Neurofibromatoses

    Glioblastoma

    Epilepsy: The Genetic Epilepsies

    Demyelinating Disease: Demyelinating Diseases

    Neuropathies and Neuronopathies:

    Peripheral Neuropathies

    Spinal Muscular Atrophies

    Pain disorders

    Congenital Myasthenic Syndromes

    Myopathies:

    Dystrophinopathies

    Limb-Girdle Muscular Dystrophies

    The Congenital Myopathies

    The Distal Myopathies

    Hereditary Inclusion-Body Myopathies

    The Myotonic Dystrophies

    Facioscapulohumeral Dystrophy

    Other Ion Channel Disorders

    Dermatologic and Brain Disorders:

    The Phakomatoses

    Lipoprotein Disorders

    Apolipoprotein E: Structure and Function in Lipid Metabolism and Neurobiology /

    Cerebrotendinous Xanthomatosis

    Stroke:

    The genetics of stroke

    Metabolic Disorders:

    Disorders of Lipid Metabolism

    Glycogen Storage Diseases / Disorders of Galactose Metabolism

    Inborn Errors of Amino Acid Metabolism

    Disorders of the Urea Cycle

    Disorders of Glucose Transport

    Maple Syrup Urine Disease: Clinical and Biochemical Perspectives

    Congenital Disorders of N-linked Glycosylation

    Disorders of Glutathione Metabolism

    Canavan Disease

    Purines

    Porphyrias

    Metal Metabolism

    Wilson Disease

    Menkes Disease

    Neurodegeneration with Brain Iron Accumulation

    Vitamins:

    Genetic and Dietary Influences on Life Span

    Vitamins: Cobalamin and Folate

    Disorders of Biotin Metabolism

    SECTION III. PSYCHIATRIC DISEASE

    Psychiatric Diseases: Challenges in Psychiatric Genetics

    Depression

    Bipolar Disorder

    Schizophrenia

    Obsessive-Compulsive Disorder

    Tourette's Syndrome

    Genetic Bases of Addictive Behaviors

    Autism

    SECTION IV. A NEUROLOGIC AND PSYCHIATRIC GENE MAP

    A Neurologic and Psychiatric Gene Map

     

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