Restless Legs Syndrome book cover

Restless Legs Syndrome

Recognized international leaders in the field of restless legs syndrome bring you their expertise in this clinically-focused, practical resource. Understand the various causes of this common movement and sleep disturbance and identify the best treatment options in each case. The text provides comprehensive overviews of both pharmacologic and non-pharmacologic approaches, covering benefits, limitations, and side-effect profiles. No matter what your specialty, if you treat any patients with restless legs syndrome, this book has everything you need to offer them the best care possible.

Sleep Medicine/Neurology


Published: April 2009

Imprint: Saunders

ISBN: 978-0-7506-7518-5


  • I. Introduction

    1. General Introduction: Restless Legs Syndrome as a Neurological Conundrum, Werner Poewe

    2. Introduction: The Patient’s Perspective, Robert Balkam

    3. From 1685 to 2008: An Introduction to the Restless Legs Syndrome, Allison Chan and Christian Guilleminault

    4. Introduction: Restless Legs Syndrome as a Movement Disorder, Stanley Fahn

    5 Restless Legs Syndrome and Nocturnal Myoclonus (Periodic Limb Movements during Sleep): An Historical Review, Elio Lugaresi and Federica Provini

    6 Introduction: Clinical Science of Restless Legs Syndrome, Sudhansu Chokroverty

    II. Basic Science of Restless Legs Syndrome

    A. Epidemiology and Genetics

    7 The Epidemiology of Restless Legs Syndrome, Klaus Berger and Tobias Kurth

    8 Genetics of Restless Legs Syndrome, Lan Xiong, Gustavo Turecki, Anastasia Levchenko, Claudia Gaspar, Wayne A. Hening, Jacques Montplaisir, Guy A. Rouleau

    B. Pathophysiology

    9 The Iron Metabolic System, Stacey L. Clardy, James R. Connor, and John Beard

    10 Iron Dysregulation in Restless Legs Syndrome, Christopher J. Earley

    11 The Brain’s Dopamine Systems and their Relevance to Restless Legs Syndrome, A. A. Freeman and D. B. Rye

    12 Neuroimaging in Restless Legs Syndrome, Claudia Trenkwalder and Christopher J. Earley

    13 Circadian Rhythm of Restless Legs Syndrome, Diego Garcia-Borreguero and Wayne A. Hening

    14 Spinal Cord, Dopamine, Opiates and Restless Legs Syndrome, W. Paulus and E.D. Schomburg

    III. Clinical Science of RLS

    A. Diagnosis

    15 Diagnosis of Restless Legs Syndrome, Richard P. Allen

    16 Differential Diagnosis of Restless Legs Syndrome, Sudhansu Chokroverty

    17 Periodic Limb Movements in Sleep (PLMS), Federica Provini, Roberto Vetrugno, Pasquale Montagna, and Raffaele Ferri

    18 Sleep Laboratory Diagnosis of Restless Legs Syndrome, Jacques Montplaisir, Martin Michaud, Marie-Hélène Pennestri, and Paola Lanfranchi

    19 Actigraph Assessment of Periodic Leg Movements (PLM) and Restless Legs Syndrome (RLS), Richard P. Allen and Wayne A. Hening

    20 Assessment of Restless Legs Syndrome Features with Standardized Methods, Heike Benes and Ralf Kohnen

    B. Co-Morbidities and Special Populations

    21 Restless Legs Syndrome and Periodic Limb Movement Disorder in Childhood and Adolescence, Daniel L. Picchietti and Arthur S. Walters

    22 Restless Legs Syndrome and Pregnancy, Mauro Manconi and Luigi Ferini-Strambi

    23 Restless Legs Syndrome and Periodic Limb Movements in the Elderly with and without Dementia, Donald L. Bliwise

    24 Restless Legs Syndrome in Medical Disorders, John W. Winkelman and Jan Ulfberg

    25 Restless Legs Syndrome in Neurological Disorders, William Ondo and Michael Polydefkis

    26 Is the Manifestation of the Restless Legs Syndrome Related to a Pain Mechanism?, Danièle Laverdure-Dupont, Gilles Lavigne, Jacques Montplaisir, and Peter Soja

    27 Restless Legs Syndrome and Psychiatric Disorders, Hochang Ben Lee and Wayne A. Hening

    C. Management

    28 Overview of Management, Wayne A. Hening

    29 Non-Pharmacologic Considerations and Treatment of Restless Legs Syndrome, Mark J. Buchfuhrer and Jill Gunzel

    30 Dopaminergic Therapy of Restless Legs Syndrome, Michael H. Silber and Richard P. Allen

    31 Opioid Agents in the Treatment of Restless Legs Syndrome, Phillip M. Becker

    32 The Use of Anti-convulsants in Treatment of Restless Legs Syndrome, Diego Garcia-Borreguero and Mark Buchfuhrer

    33 Iron Treatment, Christopher J. Earley

    34 Additional Agents and Miscellaneous Therapies, Mark Buchfuhrer and Wayne Hening

    35 Management of Restless Legs Syndrome in Hospital and during Surgery, Birgit Högl and Viola Gschliesser

    36 Restless Legs Syndrome Morbidity: Sleep and Quality of Life, Richard P. Allen, Heike Benes, and Ralf Kohnen

    37 History of the Restless Legs Syndrome Foundation, Georgianna Bell and Pickett Guthrie
    Summary, Wayne A. Hening


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