Renal Physiology

Mosby Physiology Monograph Series (with Student Consult Online Access)


  • Bruce Koeppen, MD, PhD, Dean Frank H. Netter MD School of Medicine Quinnipiac University Hamden, Connecticut
  • Bruce Stanton, PhD, Professor of Microbiology and Immunology, and of Physiology, Andrew C. Vail Memorial Professor, Dartmouth Medical School, Hanover, NH

Renal Physiology helps you to quickly and easily grasp the fundamentals of renal physiology and learn how to apply them in a clinical context. Thoroughly updated, this medical textbook in the Mosby Physiology Monograph Series provides a basic understanding of normal kidney function at the cellular and molecular level. Attractively illustrated with clear 2-color diagrams, it also facilitates study with learning objectives, "In the Clinic" and "At the Molecular Level" boxes, chapter summaries, and clinical cases with review questions and explained answers. Online access at makes this an even more accessible powerful learning resource.
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Book information

  • Published: October 2012
  • Imprint: MOSBY
  • ISBN: 978-0-323-08691-2


"The book is very laid out and over the first  few chapters and with several excellent diagrams the physiology and anatomy of the kidneys is very well explained...This book is well referenced with up to date evidence supporting all statements and will make a great addition to any physiotherapist's library. It will give you a good overview and understanding of renal physiology and how this affects other bodily systems. Moreover this book is important asset holds an array of transferable information which you an apply to the specialised field you work in."

In Touch, January 2014

Table of Contents

Introduction to the Kidney

1 Physiology of Body Fluids

Physicochemical Properties of Electrolyte Solutions
Molarity and Equivalence
Osmosis and Osmotic Pressure
Osmolarity and Osmolality
Oncotic Pressure
Specific Gravity
Volumes of Body Fluid Compartments
Composition of Body Fluid Compartments
Fluid Exchange Between Body Fluid Compartments
Capillary Fluid Exchange
Cellular Fluid Exchange
Key Words and Concepts
Self-Study Problems

2 Structure and Function of the Kidneys

Structure of the Kidneys
Gross Anatomy
Ultrastructure of the Nephron
Ultrastructure of the Glomerulus
Ultrastructure of the Juxtaglomerular Apparatus
Innervation of the Kidneys
Key Words and Concepts
Self-Study Problems

3 Glomerular Filtration and Renal Blood Flow

Renal Clearance
Glomerular Filtration Rate
Glomerular Filtration
Determinants of Ultrafiltrate Composition
Dynamics of Ultrafiltration
Renal Blood Flow
Regulation of Renal Blood Flow and Glomerular Filtration Rate
Sympathetic Nerves
Angiotensin II
Nitric Oxide
Natriuretic Peptides
Key Words and Concepts
Self-Study Problems

4 Renal Transport Mechanisms: NaCl and Water Reabsorption Along the Nephron

General Principles of Membrane Transport
General Principles of Transepithelial Solute and Water Transport
NaCl, Solute, and Water Reabsorption Along the Nephron
Proximal Tubule
Henle’s Loop
Distal Tubule and Collecting Duct
Regulation of NaCl and Water Reabsorption
Key Words and Concepts
Self-Study Problems

5 Regulation of Body Fluid Osmolality: Regulation of Water Balance

Antidiuretic Hormone
Osmotic Control of AVP Secretion
Hemodynamic Control of AVP Secretion
AVP Actions on the Kidneys
Renal Mechanisms for Dilution and Concentration of the Urine
The Role of Urea
Vasa Recta Function
Assessment of Renal Diluting and Concentrating Ability
Key Words and Concepts
Self-Study Problems

6 Regulation of Extracellular Fluid Volume and NaCl Balance

Concept of Effective Circulating Volume
Volume-Sensing Systems
Volume Sensors in the Low-Pressure Cardiopulmonary Circuit
Volume Sensors in the High-Pressure Arterial Circuit
Hepatic Sensors
Central Nervous System Na+ Sensors
Volume Sensor Signals
Renal Sympathetic Nerves
Renin-Angiotensin-Aldosterone System
Natriuretic Peptides
Control of Renal NaCl Excretion During Euvolemia
Mechanisms for Maintaining Constant Na+ Delivery to the Distal Tubule
Regulation of Distal Tubule and Collecting Duct Na+ Reabsorption
Control of Na+ Excretion with Volume Expansion
Control of Na+ Excretion with Volume Contraction
Alterations in Starling Forces
The Role of the Kidneys
Key Words and Concepts
Self-Study Problems

7 Regulation of Potassium Balance

Overview of K+ Homeostasis
Regulation of Plasma [K+]
Alterations of Plasma [K+]
Acid-Base Balance
Plasma Osmolality
Cell Lysis
K+ Excretion by the Kidneys
Cellular Mechanisms of K+ Transport by Principal Cells and Intercalated Cells in the Distal Tubule and Collecting Duct
Regulation of K+ Secretion by the Distal Tubule and Collecting Duct
Plasma [K+]
Arginine vasopressin (AVP)
Factors that Perturb K+ Excretion
Flow of Tubular Fluid
Acid-Base Balance
Key Words and Concepts
Self-Study Problems

8 Regulation of Acid-Base Balance

The HCO3- Buffer System
Overview of Acid-Base Balance
Renal Net Acid Excretion
HCO3- Reabsorption Along the Nephron
Regulation of H+ Secretion
Formation of New HCO3-
Response to Acid-Base Disorders
Extracellular and Intracellular Buffers
Respiratory Compensation
Renal Compensation
Simple Acid-Base Disorders
Metabolic Acidosis
Metabolic Alkalosis
Respiratory Acidosis
Respiratory Alkalosis
Analysis of Acid-Base Disorders
Key Words and Concepts
Self-Study Problems

9 Regulation of Calcium and Phosphate Homeostasis

Overview of Ca++ Homeostasis
Ca++ Transport along the Nephron
Regulation of Urinary Ca++ Excretion
Calcium-Sensing Receptor
Overview of Pi Homeostasis
Pi Transport along the Nephron
Regulation of Urinary Pi Excretion
Integrative Review of Parathyroid Hormone, Calcitriol, and Calcitonin on Ca++ and Pi Homeostasis
Key Words and Concepts
Self-Study Problems

10 Physiology of Diuretic Action

General Principles of Diuretic Action
Sites of Action of Diuretics
Response of Other Nephron Segments
Adequate Delivery of Diuretics to Their Site of Action
Volume of the Extracellular Fluid
Diuretic Braking Phenomenon
Mechanisms of Action of Diuretics
Osmotic Diuretics
Carbonic Anhydrase Inhibitors
Loop Diuretics
Thiazide Diuretics
K+-Sparing Diuretics
Effect of Diuretics on the Excretion of Water and Other Solutes
Solute-Free Water
K+ Excretion
HCO3- Excretion
Ca++ and Pi Excretion
Key Words and Concepts
Self-Study Problems

Additional Reading

APPENDIX A Integrative Case Studies
APPENDIX B Normal Laboratory Values
APPENDIX C Nephron Function
APPENDIX D Answers to Self-Study Problems
APPENDIX E Answers to Integrative Case Studies
APPENDIX F Review Examination