Regenerative Nephrology book cover

Regenerative Nephrology

Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts.

Audience

Medical and pharmaceutical researchers in nephrology and related renal diseases; fellows and academic clinicians in nephrology; biomedical researchers who work with stem cells.

Hardbound, 442 Pages

Published: October 2010

Imprint: Academic Press

ISBN: 978-0-12-380928-5

Reviews

  • "The authors of Regenerative Nephrology have empowered a group of the leading investigators to provide a comprehensive overview of regenerative processes in the kidney. It spans the subject from cellular physiology to models and the first clinical trials of stem cell therapy.  This book fills a gap in this rapidly expanding field. It will be an invaluable reference to the specialist investigator and a useful overview for those in nephrology or regenerative medicine who wish to become fully up to date with this important subject."--Christopher S. Wilcox, MD, PhD, George E. Schreiner Chair of Nephrology,Director, Center for Hypertension, Kidney and Vascular Health, Chief, Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC, USA

    "Dr. Goligorsky has assembled an outstanding group of authors for his "Regenerative Nephrology" book. The publication of this authoritative work is timely. State-of-the-art knowledge about the phylogeny, ontogeny, and mediators of tissue regeneration is discussed and is critical in pursuing the potential role of stem cells in regenerative processes. The kidney is the organ responsible for total body homeostasis, therefore focusing on regeneration in acute and chronic kidney disease is very appropriate. Moreover, Goligorsky is an internationally prominent researcher in understanding the pathophysiology of kidney disease. Regenerative Nephrology has important sections dealing with the clinical aspects of stem cell therapy including potential risks and ethical issues. I highly recommend this important book, not just for scientists studying the kidney, but for all biomedical scientists, as the dawn of stem cell therapy in humans is emerging for many organs."--Robert W. Schrier, MD, Professor of Medicine, University of Colorado, School of Medicine, Denver, CO, USA

    "With this book, Dr Goligorsky, along with his impressive collection of highly prominent authors, has certainly succeeded in achieving the goal of bringing an up-to-date review of the basic research of regenerative nephrology and its promising clinical applications to the attention of the interested reader. This is a truly international book; although the majority of the outstanding faculty is North American, excellent contributions have been written by Japanese, Australian and European authors…. This book is not only of interest to the basic expert investigator. Also, the interested teacher or clinician who wants to catch a glimpse of what will become possible in the near future in the treatment of a whole range of acute and chronic kidney diseases with these fascinating new tools will find this book a must…. Dr Goligorsky and his contributors have done a great service to most of us ‘non-experts’ by summarizing, in a brilliant manner, the recent advances in this field."--NDT Plus


Contents

  • PHYLOGENY AND ONTOGENY OF TISSUE REGENERATION

    1. Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach
    2. Yuko Wakamatsu and Hisashi Hashimoto

    3. Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia
    4. Marc R. Hammerman

    5. Use of Genetic Mouse Models to study Kidney Regeneration
    6. Akio Kobayashi and Jeremy S. Duffield

      MEDIATORS OF REGENERATION

    7. Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease
    8. Charles N. Serhan and Catherine Godson

    9. Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptides Danilo Fliser
    10. Mast cells in kidney regeneration
    11. Eric Daugas, Walid Beghdadi and Ulrich Blank

    12. Role of macrophages in renal injury, repair and regeneration
    13. Vincent Lee, Qi Cao, Yiping Wang and David C.H. Harris

    14. T-cells contribution to regenerative processes
    15. Hamid Rabb

      STEM CELLS IN REGENERATIVE PROCESSES

    16. MSC and reparative processes
    17. Benjamin D. Humphreys and John V. Bonventre

    18. Stem cells in regenerative processes: Endothelial progenitor cells and the kidney
    19. Matthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink

    20. The potential of the side population in regenerative nephrology
    21. Melissa H. Little and G. A. Challen

    22. Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasis
    23. Dong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak

    24. Stem Cells in Regenerative Processes; Induced Pluripotent Stem Cells
    25. Kenji Osafune and Shinya Yamanaka

    26. Methods of Isolation and Culture of Adult Stem cells
    27. Lindolfo da Silva Meirelles and Nance Beyer Nardi

      STEM CELLS - FROM THE NICHE TO REPAIR

    28. Stem cell niche in the kidney
    29. Laura Lasagni, Elena Lazzeri and Paola Romagnani

    30. Creation of artificial niches
    31. Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff and Michael S. Goligorsky

    32. Imaging of transplanted and native stem cells
    33. Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. Lerman

      CAUSES OF REGENERATIVE FAILURE

    34. Stem cell injury and premature senescence
    35. Michael S. Goligorsky

    36. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway
    37. Nica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering

    38. BONE MARROW-MESENCHYMAL STEM CELLS IN ORGAN REPAIR AND STRATEGIES TO OPTIMIZE THEIR EFFICACY
    39. Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina Morigi

      EMERGING CLINICAL ASPECTS OF STEM CELL THERAPY

    40. Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical Data
    41. Florian E. Tögel and Christof Westenfelder

    42. Clinical trials in Renal Regenerative Medicine
    43. Maarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar

    44. Potential risks of stem cell therapies
    45. Uta Kunter and Jürgen Floege

    46. Tissue engineering in urology
    47. Anthony Atala

    48. Ethical issues in SC therapy
    49. Donald W. Landry

    50. Stem Cell Banking

    Vicente Mirabet and Pilar Solves

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