Regenerative Medicine Applications in Organ Transplantation book cover

Regenerative Medicine Applications in Organ Transplantation

Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine.

Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.


Basic and clinical researchers in the fields of regenerative medicine, transplantation, tissue engineering, biomaterial sciences, stem cell biology, developmental biology, and related fields

Hardbound, 1050 Pages

Published: November 2013

Imprint: Academic Press

ISBN: 978-0-12-398523-1


  • "…an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession."--Transplantation, Nov 27 2014

    "Given the implications that a chronic shortage of organs has on public health and society, this book is a valuable resource for students and professionals seeking to do something about this problem by taking advantage of cutting-edge developments in one of those most dynamic scientific disciplines existing today, namely regenerative medicine."--Regenerative Medicine 2014 9(3)
    "The text is well organized…Chapters on tracheal reconstruction and bladder reconstruction are impressive in demonstrating proximity to clinical utility and indicate that simple structural elements can be manufactured and implanted in humans to bridge a limited defect…if you want to spark your enthusiasm for what is to come, then this textbook is a fine first step into the future."--American Journal of Transplantation, June 2014
    "With beautiful illustrations throughout that greatly enhance the overall reading experience of this book, this book is a must-have for anyone interested in tissue engineering and organ transplantation. This is one of the best textbooks I have come across that combines surgery with science, and it is a must for all surgeon-scientists involved in tissue engineering and organ transplantation."--BCS Online, April 3, 2014
    "This book succeeds in providing a detailed and comprehensible description of current and future therapies for solid organ replacement. It is unique in that it encompasses all solid organs and compiles a great deal of research. It will serve as a valuable reference for all those involved in the evolution of transplantation." Rating: 4 Stars--Organ Transplantation review on, January 24, 2014


  • Meet the Editors
      Giuseppe Orlando
      Roy Calne
    1. Introduction: Regenerative medicine and solid organ transplantation from a historical perspective
      Joseph P. Vacanti, Jean Bernard Otte and Jason A. Wertheim
    2. Solid organ transplantation: has the promise been kept and the needs met?
      James Neuberger and Marco Carbone

    Principles of Regenerative Medicine and Cell, Tissue, and Organ Bioengineering
    3. Strategies for the specification of tissue engineering biomaterials
      David F. Williams
    4. Principles of Stem Cell Biology
      Paolo DeCoppi
    5. Principles of cell sheet technology
      Teruo Okano
    6. Principles of bioprinting technology
      Tao Xu
    7. Synthetic biomaterial for regenerative medicine applications
      Mark Van Dyke and Aaron Goldstein
    8. Natural biomaterials for regenerative medicine applications
      S Badylak and Stephen F. Badylak
    9. Bioartificial biomaterials for regenerative medicine applications
      Gianluca Ciardelli and Valeria Chiono
    10. Bioactivated materials for cell and tissue guidance
      Paolo Antonio Netti Sr.
    11. Biocompatibility and immune response to biomaterials
      B Brown, S Badylak and Stephen F. Badylak
    12. Harnessing regenerative and immunomodulatory properties of stem cells
      Peiman Hematti
    13. Bioreactors for tissue engineering purposes
      David A. Vorp and Justin Sol Weinbaum

    14. Current status of renal transplantation
      Jeffrey Rogers
    15. Living related renal transplantation: progress, pitfalls and promise
      Nizam Mamode
    16. Machine perfusion of kidneys donated after cardiac death: the Carrel and Lindbergh legacy
      Jacques Pirenne, Ina Jochmans and Ina Jochmans
    17. Renal regeneration: the bioengineering approach
      Giuseppe Orlando
    18. Renal regeneration: the stem cell biology approach
      Laura Perin
    19. Renal regeneration: the developmental approach
      S Nigam

    20. Current status of liver transplantation
      Jan Lerut
    21. Living related liver transplantation: progress, pitfalls and promise
      Jan Lerut
    22. Donation after cardiac death liver transplantation
      Paolo Muiesan
    23. Artificial liver support
      Xavier Wittebole and Pierre-Francois Laterre
    24. Liver regeneration: the bioengineering approach
      Basak E. Uygun and K Uygun
    25. Liver regeneration: the developmental biology approach
      D A. Rudnick
    26. Liver regeneration: the stem cell approach
      Gianfranco Alpini and Shannon Glaser
    27. Liver bioengineering using human cells
      Shay Soker

    28. Current status of heart transplantation
      Mandeep Mehra and Sunu Thomas
    29. Artificial heart support
      Oliver Van Caenegem and Luc Marie Jacquet
    30. Heart regeneration: the bioengineering approach
      Dror Seliktar
    31. Heart regeneration: the developmental and stem cell biology approach
      Timothy Nelson

    Small Bowel
    32. Current status of intestinal transplantation
      Gennaro Selvaggi and Andreas Tzakis
    33. Living related small bowel transplantation: progress, pitfalls and promise
      Ivo G. Tzvetanov, Lorena Bejarano-Pineda and Enrico Benedetti
    34. Intestinal regeneration: the bioengineering approach
      Khalil N. Bitar
    35. Intestinal regeneration: the developmental biology approach
      Jose E. Garcia-Arraras
    36. Intestinal regeneration: stem cell approach
      T C. Grikscheit
    37. Building blocks for engineering the small intestine
      M Wong

    Endocrine pancreas and islets of Langerhans
    38. Current status of pancreas transplantation
      George W. Burke III, Gaetano Ciancio and M Chavez
    39. Living related pancreas transplantation: progress, pitfalls and promise
      Rainer W. Gruessner
    40. Current status of islet transplantation
      Giuseppe Remuzzi
    41. Pancreatic islets regeneration: the bioengineering approach
      Giuseppe Orlando and Shay Soker
    42. Pancreatic islet regeneration: the developmental and stem cell biology approach
      Juan Dominguez-Bendala, Camillo Ricordi, Giacomo Lanzoni and Luca Inverardi
    43. Microencapsulation technology
      E C. Opara
    44. Autologous islets transplantation
      Alan C. Farney

    45. Current status of lung transplantation
      Dirk Emiel Van Raemdonck and Toni Lerut
    46. Living related lung transplantation: progress, pitfalls and promise
      Hiroshi Date, T Horacic and S Seiko
    47. Artificial Lung Support
      Shaf Keshavjee
    48. Lung regeneration: the bioengineering approach
      Joan E. Nichols
    49. Lung regeneration: the developmental biology approach
      S Janes
    50. Lung regeneration: stem cell approach
      Shigeo Masuda

    Composite tissues allotransplantation
    51. Current status of CTA
      Jean-Michel Dubernard and Palmina Petruzzo
    52. The Neourinary Conduit
      Anthony Atala
    53. Upper airways bioengineering
      Paolo Macchiarini
    54. Skin regeneration and bioengineering
      Dennis P. Orgill and Ryan Gobble
    55. The Use of Skin Substitutes in the Treatment of Burns
      Alexander Marcus Seifalian
    56. Bone regeneration and bioengineering
      Ranieri Cancedda
    57. Nerve regeneration and bioengineering
      Tina Sedaghati and Alexander Marcus Seifalian
    58. Vessel bioengineering
      Toshiharu Shinoka and Christopher Kane Breuer
    59. Corneal bioengineering
      Michele De Luca and Graziella Pellegrini
    60. Esophagus bioengineering
      Paolo DeCoppi

    Immunosuppression-free transplantation in the regenerative medicine era
    61. Stem cell-based approach to immunomodulation
      Kathryn Wood
    62. Immunosuppression-free renal transplantation
      Fred Faendrich
    63. Immunosuppression-free liver transplantation
      Tommaso Maria Manzia, Giuseppe Tisone and Leonardo Baiocchi
    64. Biomarkers of tolerance in liver transplantation
      Takaaki Koshiba
    65. Biomarkers of tolerance in renal transplantation
      Jean-Paul Soulillou, Sophie Brouard and Faouzi Braza
    66. Immunocloacking
      Lauren Brasile
    67. The need for immune modulation despite regenerative medicine
      Lucienne Chatenoud
    68. Stem cells approach to I/R injury
      Eiji Kobayashi and Takumi Teratani
    69. Xenotransplantation: past, present and future
      Pierre Gianello
    70. Regenerative medicine as an industry
      Paolo Antonio Netti Sr. and Alessandro Sannino
    71. Ethics in regenerative medicine and transplantation
      Nancy M P King
    Epilogue: Organ Bioengineering and Regeneration as the new Holy Grail of Organ Transplantation
      Giuseppe Orlando


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