Reflections on a Century of Malaria Biochemistry

1. An Introduction to Malaria Parasites 2. The Early Years 3. Show Me The Money 4. In vivo and in vitro models a. Life in the Erythrocyte b. Life Outside the Erythrocyte c. Life in the Mosquito 5. Malaria Pigment 6. Chloroquine and Hemozoin 7. Isoenzymes 8. The Road to the Plasmodium falciparum Genome 9. Carbohydrate metabolism a. Glycolysis and the TCA Cycle b. The Pentose Phosphate Pathway c. Pyridine nucleotides d. Carbon dioxide fixation 10. Pyrimidines and the Mitochondrion 11. The Road to Atovaquone 12. The Ring Road to the Apicoplast 13. Ribosomes and Ribosomal RNA Synthesis 14. De Novo Synthesis of Pyrimidines and Folates 15. Salvage of Purines 16. Polyamines 17. New Permeability Pathways and Transport 18. Hemoglobinases 19. Membrane Proteins 20. Trafficking 21. Membrane Lipids 22. Adhesion a. Adhesion Without Knobs b. Cerebral Malaria 23. Invasion 24. Vitamins and Antioxidants 25. Shocks and Clocks 26. Transcriptomes, Proteomes and Data Mining 27. Mosquito Interactions