Receptor Chemistry Towards the Third Millennium
- U. Gulini
- M. Gianella
- W. Quaglia
- G. Marucci, Department of Chemical Sciences, Camerino, Italy
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Receptor Chemistry Towards the Third Millennium is the result of papers presented at the 12th Camerino-Noordwijkerhout Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned, many aspects still remain to be explored. In particular, differentiation into distinct subpopulations and the multiplicity of transduction processes offer more specific targets in the search for new drugs.
This book will be of interest to medicinal chemists, pharmacologists, biochemists and neurologists and will also be a valuable source of reference for medical students and postgraduate students in related fields.
- Published: May 2000
- Imprint: ELSEVIER
- ISBN: 978-0-444-50424-1
Table of ContentsPharmacological receptors: A century of discovery - and more (D.J. Triggle). Cholinergic receptors and neurodegenerative diseases (F. Gualtieri). Nicotinic systems in central nervous systems disease: Degenerative disorders and beyond (P. Newhouse). Central nicotinic receptor ligands and pharmacophores (R.A. Glennon). Structural aspects of high affinity ligands for the alpha4beta 2 neuronal nicotinic receptor (M.J. Dart). Recombinant human receptors and functional assays in the discovery of novel acetylcholine-gated ion channel (nAchR)Agonist (N.D.P. Cosford). Receptors in neurodegenerative diseases. Muscarinic cholinergic receptors (P. Angeli). Design and development of selective muscarinic agonists for the treatment of alzheimer's disease (W.S. Messer). Cl-1017 a functionally M1 selective muscarinic agonist: design synthesis and preclinical pharmacology (H. Tecle). Ligands for the common allosteric site of acetylcholine M2-receptors: development and application DEU (U. Holzgrabe). Receptors in cardiovascular disease: review and introduction (A. Leonardi). Adrenoceptor subclassification: an approach to improved cardiovascular therapeutics (J.P. Hieble). The alpha 1 a and alpha 1 b-adrenergic receptor subtypes: molecular mechanisms of receptor activity (S. Cotecchia). Alfa1-Adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety (C. Melchiorre). Selection design and evaluation of new radioligands for pet studies of cardiac adrenoceptors (V.W. Pike). Enigmatic receptors (L. Brasili). Imidazoline receptors: A challenge (P. Bosquet). Sigma receptors: recent advances and new clinical potentials (W. Bowen). Excitatory amino acid receptors (G. Gaviraghi). Excitatory amino acid agonists and antagonists: Pharmacology and therapeutic applications (D. Trist). Metabotropic glutamate receptors: A structural view point (R. Pellicciari). Synthesis and pharmacological properties of novel glicine antagonists (D. Donati). Introduction to receptors in neurodegenerative diseases (W. Froestl). Neurotrophin receptor structure and interactions (M.V. Chao). The RET receptor tyrosine kinase: activation signalling and significance in neural development and GBR (I.J. Mason). The ciliary neurotrophic factor (CNTIF) and its receptor CNTIFR alpha (M. Sleeman ). Rediscovering good old friend IGF-1 in the new millennium (R. Quirion). Apoptosis induced by death receptors (P. Schneider). Hijacked receptors (D.J. Triggle). ICAM-1 receptors and cold viruses (J. Bella). Viral-encoded G-protein coupled receptors: new targets for drug research? (M.J. Smit). Chemokine receptors: interaction with HIV-1 and viral-encoded chemokines (S. Sozzani). General topics and perspectives (H. Timmerman). Pharmacological evidence of muscarinic receptor heterodimerization (R. Maggio). Constitutive activity of G protein coupled receptors and drug action (R. Leurs). New dimensions in G protein signalling: Gbeta5 and the RGS proteins (W.F. Simonds). Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse (J.L. Neumeyer).