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Recent Advances in Parkinsons Disease

Part I: Basic Research

  • Anders Bjorklund
    • Angela Cenci-Nilsson

    This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods.

    Audience
    Neuroscientists, psychologists, neurologists

    Included in series
    Progress in Brain Research

Hardbound, 332 Pages

Published: August 2010

Imprint: Elsevier

ISBN: 978-0-444-53614-3

Contents

  • Section I: Genetic and molecular mechanisms of neurodegeneration in PD

    1

    Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects

    Thomas Gasser

    2

    The impact of genetic research on our understanding of Parkinson's Disease

    Ted Dawson

    Ian Martin, Valina L. Dawson

    3

    Unraveling the role of defective genes

    Mark Cookson

    4

    What causes the death of dopaminergic neurons in Parkinson’s disease?

    James Surmeier

    Jaime N. Guzman, Javier Sanchez-Padilla and Joshua Goldberg

    5

    Intracellular Signaling Pathways In Dopamine Cell Death And Axonal Degeneration

    Robert Burke

    6

    Control of mitochondrial integrity in Parkinson’s Disease

    Serge Przedborski

    Cristofol Vives-Bauza, Maja Tocilescu, Rosa L. A. deVries, Dana M. Alessi, Vernice Jackson-Lewis

    7

    Role of Post-Translational Modifications in Modulating the Structure, Function and Toxicity of a-synuclein: Implications for Parkinson’s Disease Pathogenesis and Therapies

    Hilal Lashuel

    Abid Oueslati, Margot Fournier

    Section II: Cellular and system-level pathophysiology of the basal ganglia in PD

    8

    The role of dopamine in modulating the structure and function of striatal circuits

    James Surmeier

    Weixing Shen, Michelle Day, Tracy Gertler, Savio Chan, Xianyong Tian and Joshua L. Plotkin

    9

    Assemblies of glutamate receptor subunits with post-synaptic density proteins and their alterations in Parkinson’s disease

    Monica Di Luca

    Paolo Calabresi

    10

    Adenosine-dopamine interactions

    Micaela Morelli

    Anna R Carta, Anil Kachroo, Michael A. Schwarzschild

    11

    Maladaptive plasticity in L-DOPA-induced dyskinesia

    M. Angela Cenci

    Christine Konradi

    12

    Effects of GPi and STN inactivation on physiological, motor, cognitive

    and motivational processes in animal models of Parkinson's disease

    Chistelle Baunez

    Paolo Gubellini

    13

    Computational physiology of the basal ganglia in Parkinson’s disease

    Hagai Bergman

    Michal Rivlin-Etzion, Shlomo Elias, Gali Heimer

    14

    Neurocomputational models of motor and cognitive

    deficits in Parkinson's Disease

    Michael J. Frank

    Thomas V. Wiecki

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