Rang & Dale

Rang & Dale's Pharmacology

Rang & Dale’s Pharmacology provides you with all the knowledge you need to get through your pharmacology course and beyond. Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson present a clear and accessible approach to the analysis of therapeutic agents at the cellular and molecular level through detailed diagrams, full-color illustrations, and pedagogical features. Plus, USMLE-style review questions and additional learning tools online at studentconsult.com make this the perfect resource to turn to for a full understanding of key concepts in pharmacology.


Medical students in years 1 & 2 taking a Pharmacology course and students preparing for USMLE Step 1 exam.

Paperback, 792 Pages

Published: March 2011

Imprint: Churchill Livingstone

ISBN: 978-1-4377-1933-8


  • Section 1: General principles

    1. What is pharmacology?

    2. How drugs act: general principles

    3. How drugs act: molecular aspects

    4. How drugs act: cellular aspects-excitation, contraction and secretion

    5. Cell proliferation, apoptosis, repair and regeneration

    6. Cellular mechanisms: host defence

    7. Method and measurement in pharmacology

    8. Drug absorption and distribution

    9. Drug metabolism and elimination

    10. Pharmacokinetics

    11. Pharmacogenetics, pharmacogenomics and ‘personalised medicine’

    Section 2: Chemical mediators

    12. Chemical mediators and the autonomic nervous system

    13. Cholinergic transmission

    14. Noradrenergic transmission

    15. 5-Hydroxytryptamine and the pharmacology of migraine

    16. Purines

    17. Local hormones: cytokines, biologically active lipids, amines and peptides

    18. Cannabinoids

    19. Peptides and proteins as mediators

    20. Nitric oxide

    Section 3: Drugs affecting major organ systems

    21. The heart

    22. The vascular system

    23. Atherosclerosis and lipoprotein metabolism

    24. Haemostasis and thrombosis

    25. Haemopoietic system and treatment of anaemia

    26. Anti-inflammatory and immunosuppressant drugs

    27. The respiratory system

    28. The kidney

    29. The gastrointestinal tract

    30. The control of blood glucose and drug treatment of diabetes mellitus

    31. Obesity

    32. The pituitary and the adrenal cortex

    33. The thyroid

    34. The reproductive system

    35. Bone metabolism

    Section 4: The nervous system

    36. Chemical transmission and drug action in the central nervous system

    37. Amino acid transmitters

    38. Other transmitters and modulators

    39. Neurodegenerative diseases

    40. General anaesthetic agents

    41. Analgesic drugs

    42. Local anaesthetics and other drugs affecting sodium channels

    43. Anxiolytic and hypnotic drugs

    44. Antiepileptic drugs

    45. Antipsychotic drugs

    46. Antidepressant drugs

    47. CNS stimulants and psychotomimetic drugs

    48. Drug addiction, dependence and abuse

    Section 5: Drugs used for the treatment of infections, cancer and immunological disorders

    49. Basic principles of antimicrobial chemotherapy

    50. Antibacterial drugs

    51. Antiviral drugs

    52. Antifungal drugs

    53. Antiprotozoal drugs

    54. Anthelminthic drugs

    55. Anticancer drugs

    Section 6: Special topics

    56. Individual variation and drug interaction

    57. Harmful effects of drugs

    58. Lifestyle drugs and drugs in sport

    59. Biopharmaceuticals and gene therapy

    60. Drug discovery and development


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