Protein Targeting, Transport, and Translocation

Edited by

  • Ross Dalbey, Ohio State University, Columbus, U.S.A.
  • Gunnar von Heijne, Stockholm University

This book presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields.
View full description


Researchers and students interested in all areas of protein science.


Book information

  • Published: April 2002
  • ISBN: 978-0-12-200731-6


"...Dalbey et al. have summed up what has happened so far in a rapidly moving field of modern cellular biochemistry." -EUROPEAN JOURNAL OF CHEMICAL BIOLOGY (2003) "Overall this book provides good summaries of what we know about how proteins are moved between intracellular compartments and how we have studied this problem. Students or anyone wanting to know more about protein trafficking, particularly protein translocation across membranes, will find it a useful guide." —Will Prinz for CELL (November 2002)

Table of Contents

IntroductionOverviewMethods in Protein Targeting, Translocation and TransportTargeting SequencesProtein Export in BacteriaProtein Sorting at the Membrane of the Endoplasmic ReticulumMembrane Protein Insertion into Bacteial Membranes and Endoplasmic ReticulumDisulfide Bond Formation in Prokaryotes and EukaryotesThe Unfolded Protein ResponseProtein Quality Control in the Export Pathway: The Endoplasmic Reticulum and its Cytoplasmic Proteasome ConnectionTranslocation of Proteins into MitochondriaThe Import and Sorting of Protein into ChloroplastsImport of Proteins into PeroxisomesNucleocytoplasmic Transport Protein Transport to the Yeast VacuoleThe Secretory PathwayVesicular TransportConclusion/Perspective