Protein Structure and Diseases

Edited by

  • Rossen Donev, Swansea University, Swansea, Wales, UK

Structural genomics is the systematic determination of 3D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
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Audience

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

 

Book information

  • Published: May 2011
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-381262-9


Table of Contents

  1. Graphical representation and mathematical characterization of protein sequences and applications to viral proteins
    Ambarnil Ghosh and Ashesh Nandy
  2. Structural, thermodynamic and mechanistical studies in uroporphyrinogen III synthase. Molecular basis of congenital erythropoietic porphyria
    Arola Fortian, David Castaño, Esperanza Gonzalez, Ana Laín, Juan M. Falcon-Perez and Oscar Millet
  3. Role of Fibrin Structure in Thrombosis and Vascular Disease
    Amy L. Cilia La Corte, Helen Philippou and Robert A. S. Ariëns
  4. Structural, Dynamic, and Functional Aspects of Helix Association in Membranes: a Computational View
    Anton A. Polyansky, Pavel E. Volynsky, Roman G. Efremov
  5. Proteins MOVE! Protein dynamics and long-range allostery in cell signaling
    Zimei Bu and David J. E. Callaway
  6. Structural diversity of class I MHC like molecules and its implications in binding specificities
    Md. Imtaiyaz Hassan and Faizan Ahmad