Protein Modules and Protein-Protein Interactions

Edited by

  • Joël Janin, Laboratoire d'Enzymologie et Biochemie Structurales, France

Protein modules engage in a multitude of interactions with one another and with other cellular components, notably with DNA. These interactions are a central aspect of protein function of great relevance in the post-genomic era. This volume describes a panel of approaches for analyzing protein modules and their interactions, ranging from bioinformatics to physical chemistry, to biochemistry, with an emphasis on the structure-function relationship in protein-protein complexes involved in cellular processes including signal transduction.
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Audience

Biochemists, biophysicists, molecular biologists, immunologists

 

Book information

  • Published: November 2002
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-034261-7

Reviews

"The authority, originality, and editing of the reviews are first class."
PRAISE FOR THE SERIES, —NATURE


"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
—JOURNAL OF THE AMERICAN CHEMICAL SOCIETY



Table of Contents

Protein Modules and Protein-Protein Interaction: Toward a Global ViewStructural Basis for Affinity and Specificity in Macromolecular RecognitionSequence Analysis of Multidomain Proteins: Past Perspectives and Future Directions Identification of Transiently Interacting Proteins and of Stable Protein ComplexesMolecular Recognition in Antibody-Antigen Complexes Molecular Recognition by SH2 DomainsHow SH3 Domains Recognize Proline Structural Biology of eIF4F: mRNA Recognition and Preparation in Eukaryotic Translation Initiation