Protein Kinase Inhibitors in Research and Medicine book cover

Protein Kinase Inhibitors in Research and Medicine

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of two volumes covering protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles.

Audience

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Hardbound, 496 Pages

Published: December 2014

Imprint: Academic Press

ISBN: 978-0-12-397918-6

Reviews

  • This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of two volumes covering protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment based screening, broad kinome profiling of kinase inhibitors, and designing drug resistant kinase alleles.


Contents

    1. Regulation of cAMP dependent PKA
      Susan Taylor
    2. Structural Genomics of Kinases
      Stefan Knapp
    3. Kinase inhibitor discovery
      Alex Levitski
    4. Fragment based screening
      Marc O'Reilly, Valerio Berdini, Paul Mortenson
    5. Conformation specific kinase assays and type III inhibitor discovery
      Daniel Rauh
    6. Chemical Genetic Inhibitors:
      Kevan Shokat
    7. Designing Drug Resistant Kinase Alleles
      Patrick Eyers
    8. Transcriptome sequencing for targets of kinase inhibitors
      Tarun Kapoor
    9. Broad kinome profiling of kinase inhibitors
      Kurt Vogel

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