Protein Kinase Inhibitors in Research and Medicine, Part B book cover

Protein Kinase Inhibitors in Research and Medicine, Part B

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the second of two volumes covering protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles.

Audience

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Hardbound, 496 Pages

Published: December 2014

Imprint: Academic Press

ISBN: 978-0-12-397943-8

Contents

    1. PLX: Biochemical and cellular assays for the discovery of BRAF inhibitors
      Gideon Bollag
    2. Screening kinase inhibitors in cancer cell lines to identify driver kinases.
      Jeff Settleman
    3. Pseudokinases
      Mark Lemmon
    4. Enzyme Inhibitor Kinetics for Protein Kinases
      Phil Cole
    5. Covalent inhibitors
      Nathanael Gray
    6. Covalent Reversible Inhibitors
      Jack Taunton
    7. Inhibitors of PseudoKinases
      Peter Parker
    8. Inhibitor induced pathway activation
      Neal Rosen
    9. Kinase structure and regulation
      John Kuriyan

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